The Dictyostelium Centrosome
Abstract
:1. Introduction
1.1. Centrosome Types and Centrosome Duplication
1.2. Centrosome Functions
2. Dictyostelium Centrosome Composition and Topology
2.1. Composition of the Corona
2.1.1. γ-Tubulin and Its Interactors
2.1.2. Centrosomal Microtubule-Associated Proteins
2.1.3. Further Prominent Corona Components
2.2. Composition of the Layered Core
2.2.1. Outer Core Layers
2.2.2. Central Core Layer
3. Regulation of Centrosome Duplication and Mitotic Spindle Organization
3.1. Regulatory Kinases
3.2. Mitotic Spindle Organization and Spindle Elongation
4. Centrosome-Nucleus Attachment
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Amoebozoa Dictyostelium | Opisthokonta Metazoa Homo sapiens | Opisthokonta Fungi S. cerevisiae | Opisthokonta Fungi S. pombe | Archaeplastida Arabidopsis thaliana | Excavata Trypanosoma spec. | SAR Plasmodium falciparum, Albugo spec. |
---|---|---|---|---|---|---|
Central layer(s) | ||||||
CP91 [33] | - | - | - | - | - | - |
CP75 [53] | - | - | - | - | - | - |
CP39 [53] | - | - | - | - | - | - |
Outer core layer | ||||||
Cep192 [54] | Cep192/SPD2 [55] | - | - | - | - | - |
CP55 [56] | - | - | - | - | - | - |
Nek2 [57] | Nek2 [58] | Kin3p [59] | Fin1 [60] | AtNek2 [61] | TbNRKC [62] | Pfnek-2 [63] |
CP44 [64] | - | - | - | - | - | - |
Corona | ||||||
γ-tubulin [65] | γ-tubulin [5] | Tub4 [66] | gtb1 [67] | γ-tubulin [68] | γ-tubulin [69] | γ-tubulin [70] |
Spc97 [65] | GCP2 | Spc97 [66] | Alp4 [67] | GCP2 [68] | GCP2 [69] | GI: 389585322 |
Spc98 [65] | GCP3 | Spc98 [66] | Alp6 [67] | GCP3 [68] | GCP3 [69] | GI: 389585419 |
CDK5RAP2/Cep161 [71] | CDK5RAP2/Cep215/Cnn [72] | Spc72p [73] | Mto1/Mbo1/Mod20 [74] | - | GI: 407424972 | GI: 23479271 |
CP148 [75] | Pericentrin/PCNT/PLP [76] | Spc110p [73] | Pcp1 [77] | - | - | GI: 325186828 |
TACC [78] | TACC/Maskin [79] | - | Alp7/Mia1 | GI: 297312240 | - * | GI: 325183149 |
CP224 [80] | chTOG/XMAP215 [81] | Stu2p [82] | Dis1/Alp14 [83] | MOR1 [84] | XMAP215 [85] | GI: 1976646509 |
EB1 [86] | EB1 [87] | YEB1/Bim1p [88] | Mal3 [89] | EB1c [90] | EB1 | EB1 |
Moe1 [91] | eIF-3 subunit 7 | - | Moe1 [92] | eIF-3 subunit 7 | eIF-3 subunit 7 | eIF-3D |
CP248/CP250 [64,93] | C-Nap1/Cep250 [94] | - | - | - | - | - |
CenA/DdCrp [95] | Centrin-3 [96] | Cdc31p [97] | Cdc31 [98] | Centrin [99] | Centrin [100] | Centrin [101] |
CP103 [64] | - | - | - | - | - | - |
Corona-associated | ||||||
Dynein DHC [102,103] | DHC [104] | Dyn1p [105] | Dhc1 [106] | - | DHC [107] | DHC [108] |
Dynactin (including p50, p62, Arp1/Centractin) (own unpubl [109]) | Dynactin [110] | Dynactin [111] | Dynactin [106] | - | Dynactin | Dynactin [112] |
Lis1 [103] | Lis1/PAFAH1B1 [113] | Pac1p [114] | - | - | SMU1 | GI: 1678234918 |
Centrosome-associated (no sublocation determined) | ||||||
AurK [115] | AuroraA/B/C [116] | Ipl1p [117] | Ark1 [118] | ATAUR1/2/3 | TcAUK1/2/3 [119] | Pfark-1/2/3 [120] |
Plk [64] | Plk1 [121] | Cdc5p [121] | Plo1 [122] | - | TbPLK [123] | - [123] |
Sun1 [124,125] | Sun1/Matefin [126] | Mps3p [127] | Sad1 [128] | Sun1 [129] | GI: 686631607 | GI: 221061315 |
Kif9 [130] | Kif9 [131] | - | - | - | - | - |
Kif12 [132] | Kif12 [133] | - | - | Kinesin-12 | - | - |
Nup53 (Meyer in prep) | Nup35 [134] | Nup53p [135] | Nup40 [136] | NUP35 [137] | TcCL_ESM01172 | GI: 325183342 |
phr2AB [138] | PPP2R5D [139] | Cdc55p [140] | Pab1 [141] | AtB beta [142] | NCBI: XP_829543 | phr2AB |
HSBP1 [143] | HSBP1 [144] | - | - | AtHSBP [145] | - | HSBP [146] |
NdrA [147] | NDR1 [148] | Cbk1p [149] | Orb6 [149] | AGC§ [150] | PK50/PK53 § [151] | AGC/AKT § |
NdrC [152] | LATS2 | Dbf2p [149] | Sid2 [149] | AGC§ [150] | PK50/PK53 § [151] | AGC/AKT § [153] |
SepA [154] | - | Cdc15p [155] | Cdc7 [156] | - | - | - |
Spg1 [154] | - | Tem1p [157] | Sid3 [158] | AtSGP1 [159] | - | - |
SvkA/Hrk-Svk [160] | MST1/2 [161] | Kic1p [162] | Sid1 [158] | SIK1 [163] | GI: 1919796340 | - $ [164] |
NumA1 [165] | BRCT domain proteins & | BRCT domain proteins & | BRCT domain proteins & | BRCT domain proteins & | BRCT domain proteins & | BRCT domain proteins & |
fttB [52] | 14-3-3 | |||||
Clathrin light chain (clcA) [166] | CLC [167] | Clc1p [168] | Clc1 [169] | CLC2 [170] | TcClc [171] | GI: 124809181 |
AbpF [172] | - | - | - | - | - | - |
AdcA [173,174] | b-arrestin 2 [175] |
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Gräf, R.; Grafe, M.; Meyer, I.; Mitic, K.; Pitzen, V. The Dictyostelium Centrosome. Cells 2021, 10, 2657. https://doi.org/10.3390/cells10102657
Gräf R, Grafe M, Meyer I, Mitic K, Pitzen V. The Dictyostelium Centrosome. Cells. 2021; 10(10):2657. https://doi.org/10.3390/cells10102657
Chicago/Turabian StyleGräf, Ralph, Marianne Grafe, Irene Meyer, Kristina Mitic, and Valentin Pitzen. 2021. "The Dictyostelium Centrosome" Cells 10, no. 10: 2657. https://doi.org/10.3390/cells10102657