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Stick around: Cell–Cell Adhesion Molecules during Neocortical Development

Neural Development Laboratory, Instituto Universitario de Biomedicina y Biotecnología (BIOTECMED) and Departamento de Biología Celular, Facultat de Biología, Universidad de Valencia, 46100 Burjassot, Spain
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2021, 10(1), 118; https://doi.org/10.3390/cells10010118
Received: 1 December 2020 / Revised: 29 December 2020 / Accepted: 7 January 2021 / Published: 10 January 2021
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Neocortical Circuit Formation)
The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classical cadherins and nectins, as well as in their effectors, in the control of fundamental processes related with corticogenesis, with special attention in the cooperative actions among the two families of C-CAMs. View Full-Text
Keywords: CAMs; classical cadherins; nectins; neocortical development; radial glia cells; neurons; neuronal migration; axon targeting; synaptogenesis; neurodevelopmental disorders CAMs; classical cadherins; nectins; neocortical development; radial glia cells; neurons; neuronal migration; axon targeting; synaptogenesis; neurodevelopmental disorders
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MDPI and ACS Style

de Agustín-Durán, D.; Mateos-White, I.; Fabra-Beser, J.; Gil-Sanz, C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells 2021, 10, 118. https://doi.org/10.3390/cells10010118

AMA Style

de Agustín-Durán D, Mateos-White I, Fabra-Beser J, Gil-Sanz C. Stick around: Cell–Cell Adhesion Molecules during Neocortical Development. Cells. 2021; 10(1):118. https://doi.org/10.3390/cells10010118

Chicago/Turabian Style

de Agustín-Durán, David, Isabel Mateos-White, Jaime Fabra-Beser, and Cristina Gil-Sanz. 2021. "Stick around: Cell–Cell Adhesion Molecules during Neocortical Development" Cells 10, no. 1: 118. https://doi.org/10.3390/cells10010118

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