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Review

New Molecular Players in the Development of Callosal Projections

by 1 and 1,2,*
1
Center for Neuroscience Research, Children’s Research Institute, Children’s National Hospital, Washington, DC 20010, USA
2
Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 29; https://doi.org/10.3390/cells10010029
Received: 5 December 2020 / Revised: 18 December 2020 / Accepted: 23 December 2020 / Published: 26 December 2020
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Neocortical Circuit Formation)
Cortical development in humans is a long and ongoing process that continuously modifies the neural circuitry into adolescence. This is well represented by the dynamic maturation of the corpus callosum, the largest white matter tract in the brain. Callosal projection neurons whose long-range axons form the main component of the corpus callosum are evolved relatively recently with a substantial, disproportionate increase in numbers in humans. Though the anatomy of the corpus callosum and cellular processes in its development have been intensively studied by experts in a variety of fields over several decades, the whole picture of its development, in particular, the molecular controls over the development of callosal projections, still has many missing pieces. This review highlights the most recent progress on the understanding of corpus callosum formation with a special emphasis on the novel molecular players in the development of axonal projections in the corpus callosum. View Full-Text
Keywords: corpus callosum; callosal projections; cerebral cortex; development; cortical neurons corpus callosum; callosal projections; cerebral cortex; development; cortical neurons
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MDPI and ACS Style

Ku, R.Y.; Torii, M. New Molecular Players in the Development of Callosal Projections. Cells 2021, 10, 29. https://doi.org/10.3390/cells10010029

AMA Style

Ku RY, Torii M. New Molecular Players in the Development of Callosal Projections. Cells. 2021; 10(1):29. https://doi.org/10.3390/cells10010029

Chicago/Turabian Style

Ku, Ray Yueh, and Masaaki Torii. 2021. "New Molecular Players in the Development of Callosal Projections" Cells 10, no. 1: 29. https://doi.org/10.3390/cells10010029

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