Application of conventional synthetic pesticides and agrochemicals has boosted the yield and productivity of crops by reducing pest infestation and promoting crop growth yet increasing reliance on many of these products poses serious environmental threats. This has led to growing interest in obtaining more environmentally friendly alternatives to conventional pesticides and agrochemicals. Allelochemicals produced by plants, fungi, and microbes offer options for developing novel natural product-based pesticides and agrochemicals that are effective but with lower environmental half-lives. Here, we review the current state of knowledge about the potential use of juglone (5-hydroxy-1,4-naphthoquinone), the allelochemical produced by black walnut trees (Juglans nigra
), which has been investigated for applications across a range of different agricultural purposes. We then offer our perspective on what opportunities and challenges exist for harnessing juglone as a component of sustainable agriculture.
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