Inhibition of the urease activity of ruminal microbiota is not only beneficial for increasing dietary and endogenic urea-N utilization efficiency in ruminants but also might be applicable for the preservation of nitrogen fertilizer in soil and treatm...
Inhibition of ruminal microbial urease is of particular interest due to its crucial role in regulating urea-N utilization efficiency and nitrogen pollution in the livestock industry. Acetohydroxamic acid (AHA) is currently the only commercially avail...
Studies on enzyme inhibition remain a crucial area in drug discovery since these studies have led to the discoveries of new lead compounds useful in the treatment of several diseases. In this study, protocatechuic acid (PCA), an active compound from...
Up to 58% of NH3 emissions can be reduced through the use of the urease inhibitor Atmowell® in cattle farming. Automated manure scraper and drag hose systems should be used to apply urease inhibitors (UIs) to stable floors. Proof of safe use is a...
Substantial ammonia (NH3) losses from rice production result in poor nitrogen (N) use efficiency and environmental damage. A data synthesis using the published literature (127 studies with 700 paired observations), combined with an incubation experim...
Straw return in rice (Oryza sativa L.) paddy has been heavily criticized for its potential to influence ammonia (NH3) volatilization loss due to irrational fertilizer N application. Therefore, improving the N fertilization strategies within residue s...
Urea granule dissolution in soil and soil urease activity are essential parameters for the accurate prediction of nitrogen dynamics after urea application, but both are scarcely studied. The response of urease activity to temperature is unclear under...
Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustati...
The development of new anti-ureolytic compounds is of great interest due to the newly discovered role of urease inhibitors in crop protection. Purine degradation and the generation of ammonium by urease are required for the full virulence of biotroph...
Soil bacteria can produce urease, which catalyzes the hydrolysis of urea to ammonia (NH3) and carbamate. A variety of urease inhibitors have been proposed to reduce NH3 volatilization by interfering with the urease activity. We report a quantum mecha...
Urease, a pivotal enzyme in nitrogen metabolism, plays a crucial role in various microorganisms, including the pathogenic Helicobacter pylori. Inhibiting urease activity offers a promising approach to combating infections and associated ailments, suc...
Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate (py...
Urease and nitrification inhibitors represent ways to reduce nitrogen losses; their presence modifies microbial and enzymatic activity in the soil, affecting pH and organic matter (OM), which in turn affects the mobility of heavy metals. To evaluate...
Stomach infection with Helicobacter pylori (H. pylori) causes severe gastroduodenal diseases in a large number of patients worldwide. The H. pylori infection breaks up in early childhood, persists lifelong if not treated, and is associated with chron...
The field experiment was performed in 2019–2021 at the Experimental Station of Vytautas Magnus University Agriculture Academy (54°52′ N, 23°49′ E). The soil of the experimental field was Endohipogleyic-Eutric Planasol. The s...
Optimizing nitrogen (N) availability to plants is crucial for achieving maximum crop yield and quality. However, ensuring the appropriate supply of N to crops is challenging due to the various pathways through which N can be lost, such as ammonia (NH...
After evaluating the ecological and economic aspects, it is predicted that the use of urease inhibitors and biological preparations should reduce the risk of nutrient leaching by using fertilizers containing amide, ammonium, and nitrate forms of nitr...
Carbon and nitrogen compounds in agroecosystems have attracted much attention in recent years due to their key roles in crop production and their impacts on environment quality and/or climate change. Since fertilization profoundly disrupted the C and...
This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (3a–j) as Jack bean urease inhibitors. The synthesized hybrids were assayed for their in vitro urease inhibition. Accordingly, N-(adamantan-1-yl...
Nitrification inhibitor (NI) and urease inhibitor (UI) with fertilizer have the potential to reduce nitrogen (N) loss as well as improve grain yields. Urea–ammonium nitrate (UAN) solution as liquid fertilizer is superior to conventional solid n...
Currently, nitrogen fertilizers are utilized to meet 48% of the total global food demand. The demand for nitrogen fertilizers is expected to grow as global populations continue to rise. The use of nitrogen fertilizers is associated with many negative...
One-time fertilization with controlled-release urea (CRU) is a research hotspot for its lower labor cost and stability of nitrogen (N) supply for rice growth. Yet the fertilizer formulation needs to be further improved to better adjust the N suppleme...
In a wheat/maize rotation system, nitrogen (N) accounts for a large proportion of basal fertilizer, but soil N loss and the resulting environmental risk simultaneously exist worldwide. This study applied different urease/nitrification inhibitors toge...
Urea (U) is the most important nitrogen (N) fertilizer in agriculture worldwide, and as N fertilizer can result in large gaseous losses of NH3 and N2O. Thus, urease inhibitors (UIs) and nitrification inhibitors (NIs) have been coupled with U fertiliz...
The one-pot fashion of three multi-component reaction provides the desired hydroacridinone-based hydrazino-s-triazine scaffold 4. Compound 4 was crystallized in an orthorhombic crystal system and Pbca space group with a = 11.6271(2) Å, b = 18.2...
The application of urease inhibitors (UIs) and optimizing nitrogen (N) split application ratio (NSR) can both minimize ammonia (NH3) volatilization and increase rice yield. However, few studies have analyzed the combined effects of these two practice...
Synthesis of thiazolidinone based on quinolone moiety was established starting from 4-hydroxyquinol-2-ones. The strategy started with the reaction of ethyl bromoacetate with 4-hydroxyquinoline to give the corresponding ethyl oxoquinolinyl acetates, w...
In the North China Plain (NCP), urea is applied to predominantly high-pH soils and high gaseous losses of N are observed in the forms of ammonia (NH3) and nitrous oxide (N2O). The production of N2O and N2 is further stimulated by the addition of fres...
This three-year field study evaluated the agronomic and physiological responses of Tritordeum to nitrogen fertilisation strategies under Mediterranean conditions using an integrated approach combining GDD-aligned phenological monitoring, UAV-based mu...
Urea is the most used fertilizer nitrogen (N), and is often applied as urea ammonium nitrate (UAN), which may be an ammonia (NH3) emission source after application. This study examined whether the addition of urease inhibitors reduced NH3 emission, a...
Nitrogen (N) management remains a global challenge for the sustainability of diversified farming systems. Field crops are often over-supplied with nitrogen by farmers aiming to high productivity. Although the increase of nitrogen rates leads in many...
The large amount of ammonia released during agricultural application of urea fertilizer can result in a partial loss of applied nitrogen, having a detrimental effect on air quality. Although Chamomile recutita has nitrogen transformation inhibitory p...
Black mustard [Brassica nigra (L.) Koch] is mainly cultivated as a seed crop, and there is a lack of information on biomass quality and its potential for animal feeding. A 2-year field experiment was set up in a split-plot design with 2 main plots (p...
For decades, Hibiscus sabdariffa L. and its phytochemicals have been shown to possess a wide range of pharmacologic properties. In this study, aqueous extract of Hibiscus sabdariffa (AEHS) and its bioactive constituent protocatechuic acid (PCA), have...
In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were...
Enhanced efficiency fertilizers, such as urea treated with a urease inhibitor, controlled-release fertilizers (CRFs), and fertilizer blends, compose important strategies for improving efficiency in nitrogen (N) use by plants and mitigating ammonia (N...
Processes of N transformation in soil as affected by application of the three kinds of urea fertilizers, conventional urea (U), humate-coated urea (U_HA), and urea treated with the urease inhibitor NBPT (U_UI), are examined in a model laboratory expe...
Biochar (BC), nitrification inhibitors (methyl 3-(4-hydroxyphenyl) propionate, MHPP), and urease inhibitors (n-butyl phosphorothioate triamine, NBPT) have emerged as effective soil greenhouse gas (GHG) mitigation strategies in agroecosystems. However...
Urease enzyme (EC 3.5.1.5) has been determined as a virulence factor in pathogenic microorganisms that are accountable for the development of different diseases in humans and animals. In continuance of our earlier study on the helicobacter pylori ure...
Winter wheat is a widely cultivated crop that requires high inputs of nitrogen (N) fertilization, which is often connected with N losses. The application of fertilizers with nitrification (NI) and urease inhibitors (UI) is an opportunity to eliminate...
Nitrogen (N) fertilizer incorporation of efficiency enhancer is a well-established practice aiming at reducing N loss while enhancing crop yield. However, the effect of different kinds of fertilizer efficiency enhancer on N use efficiency (NUE) and g...
Broiler farming is a significant source of gaseous emissions. The aim of this study was to assess the effects of different litter additives on the emission of NH3, N2O, CO2, and CH4 during broiler housing and subsequent manure storage. The gaseous em...
Improving nitrogen use efficiency (NUE) is critical to advancing sustainable cereal production, particularly under Mediterranean conditions where environmental pressures challenge input-intensive practises. This study evaluates NUE in Tritordeum, a c...
The use of urease inhibitors in irrigated systems decreases both soil ammonium (NH4+) and nitrate (NO3−) availability, and, thus, could be an easy tool to reduce N loss due to ammonia volatilization and NO3− leaching. The main goal of this experiment...
Gastrointestinal tract infection caused by Helicobacter pylori is a common virulent disease found worldwide, and the infection rate is much higher in developing countries than in developed ones. In the pathogenesis of H. pylori in the gastrointestina...
Soil waterlogging resulting from extreme precipitation events creates anaerobic conditions that may inhibit plant growth and increase N losses. A three-year (2013–2015) field experiment was conducted in poorly-drained claypan soils to assess th...
The addition of fertilizers is indispensable in agricultural production, and currently, there is a wide variety of new types of fertilizers available. For example, commonly used are stabilized fertilizers with inhibitors and coated slow-release ferti...
Furan chalcone scaffolds belong to the most privileged and promising oxygen-containing heterocyclic class of compounds, which have a wide spectrum of therapeutic applications in the field of pharmaceutics, pharmacology, and medicinal chemistry. This...
Technological procedures for immobilizing agrochemical pollutants and activating soil enzymes that break down contaminants are still lacking due to industry’s ever-increasing number of new products to enhance agricultural production systems. Us...
Urease is an amidohydrolase enzyme that is responsible for fatal morbidities in the human body, such as catheter encrustation, encephalopathy, peptic ulcers, hepatic coma, kidney stone formation, and many others. In recent years, scientists have devo...
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