Next Article in Journal
Silica Treatments: A Fire Retardant Strategy for Hemp Fabric/Epoxy Composites
Next Article in Special Issue
Highly Branched Bio-Based Unsaturated Polyesters by Enzymatic Polymerization
Previous Article in Journal
Stimuli-Directed Helical Chirality Inversion and Bio-Applications
Previous Article in Special Issue
Protein-Repellence PES Membranes Using Bio-grafting of Ortho-aminophenol
Open AccessArticle

Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications

1
Department of Chemistry, University of Delhi, Delhi 110 007, India
2
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, Berlin 14195, Germany
3
Forschungszentrum für Elektronenmikroskopie, Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstraße 36a, Berlin 14195, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Katja Loos
Polymers 2016, 8(8), 311; https://doi.org/10.3390/polym8080311
Received: 14 July 2016 / Revised: 4 August 2016 / Accepted: 9 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Enzymatic Polymer Synthesis)
Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility. View Full-Text
Keywords: fluorinated amphiphilic polymers; self-assembly; nanocarriers; drug encapsulation; enzymatic release fluorinated amphiphilic polymers; self-assembly; nanocarriers; drug encapsulation; enzymatic release
Show Figures

Graphical abstract

MDPI and ACS Style

Parshad, B.; Kumari, M.; Achazi, K.; Bӧttcher, C.; Haag, R.; Sharma, S.K. Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications. Polymers 2016, 8, 311. https://doi.org/10.3390/polym8080311

AMA Style

Parshad B, Kumari M, Achazi K, Bӧttcher C, Haag R, Sharma SK. Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications. Polymers. 2016; 8(8):311. https://doi.org/10.3390/polym8080311

Chicago/Turabian Style

Parshad, Badri; Kumari, Meena; Achazi, Katharina; Bӧttcher, Christoph; Haag, Rainer; Sharma, Sunil K. 2016. "Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications" Polymers 8, no. 8: 311. https://doi.org/10.3390/polym8080311

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop