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Polymers
Volume 13
Issue 19
10.3390/polym13193286
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Article

Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet

by
Jiali Wei
1,
Yiran Zhao
1,
Chen Zhou
1,
Qing Zhao
1,
Hongqian Zhong
1,
Xinyu Zhu
1,
Tianyu Fu
1,
Lin Pan
1,
Qingsen Shang
1,2,* and
Guangli Yu
1,3,*
1
Key Laboratory of Marine Drugs of Ministry of Education, and Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Qingdao Marine Biomedical Research Institute, Qingdao 266071, China
3
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
*
Authors to whom correspondence should be addressed.
Polymers 2021, 13(19), 3286; https://doi.org/10.3390/polym13193286
Submission received: 27 August 2021 / Revised: 13 September 2021 / Accepted: 21 September 2021 / Published: 26 September 2021
(This article belongs to the Special Issue Polysaccharides: Structure, Properties, and Applications)
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Abstract

Previous studies have suggested that polysaccharide from Enteromorpha clathrata (ECP) could be used as a potential prebiotic to treat dysbiosis-associated diseases. However, whether it has any therapeutic effects on obesity has not been investigated. In the present study, we explored the anti-obesity effect of ECP and illustrated that it can significantly reduce the body weight and decrease the serum levels of triacylglycerol and cholesterol in high-fat diet (HFD)-fed mice. As revealed by 16S rRNA high-throughput sequencing and bioinformatic analysis, HFD remarkably changed the composition of the gut microbiota and promoted the growth of opportunistic pathogens such as Mucispirillum, Desulfobacterota and Alphaproteobacteria in obese mice. Interestingly, ECP improved intestinal dysbiosis caused by HFD and reshaped the structure of the gut microbiota in diseased mice by increasing the abundance of butyrate-producing bacterium, Eubacterium xylanophilum, in the gut. Altogether, we demonstrate for the first time an anti-obesity effect of ECP and shed new light into its therapeutic mechanisms from the perspective of gut microbiota. Our study will pave the way for the development of ECP as new prebiotic for the treatment of obesity and its associated disorders.
Keywords: Enteromorpha clathrata; polysaccharide; obesity; Eubacterium xylanophilum; gut microbiota; prebiotic; gut dysbiosis; probiotic Enteromorpha clathrata; polysaccharide; obesity; Eubacterium xylanophilum; gut microbiota; prebiotic; gut dysbiosis; probiotic

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MDPI and ACS Style

Wei, J.; Zhao, Y.; Zhou, C.; Zhao, Q.; Zhong, H.; Zhu, X.; Fu, T.; Pan, L.; Shang, Q.; Yu, G. Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet. Polymers 2021, 13, 3286. https://doi.org/10.3390/polym13193286

AMA Style

Wei J, Zhao Y, Zhou C, Zhao Q, Zhong H, Zhu X, Fu T, Pan L, Shang Q, Yu G. Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet. Polymers. 2021; 13(19):3286. https://doi.org/10.3390/polym13193286

Chicago/Turabian Style

Wei, Jiali, Yiran Zhao, Chen Zhou, Qing Zhao, Hongqian Zhong, Xinyu Zhu, Tianyu Fu, Lin Pan, Qingsen Shang, and Guangli Yu. 2021. "Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet" Polymers 13, no. 19: 3286. https://doi.org/10.3390/polym13193286

APA Style

Wei, J., Zhao, Y., Zhou, C., Zhao, Q., Zhong, H., Zhu, X., Fu, T., Pan, L., Shang, Q., & Yu, G. (2021). Dietary Polysaccharide from Enteromorpha clathrata Attenuates Obesity and Increases the Intestinal Abundance of Butyrate-Producing Bacterium, Eubacterium xylanophilum, in Mice Fed a High-Fat Diet. Polymers, 13(19), 3286. https://doi.org/10.3390/polym13193286

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