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Conformation and Dynamics of Long-Chain End-Tethered Polymers in Microchannels

Institute for Nano- and Microfluidics, Technische Universität Darmstadt, 64287 Darmstadt, Germany
Institut für Computerphysik, Universität Stuttgart, 70569 Stuttgart, Germany
Author to whom correspondence should be addressed.
Polymers 2019, 11(3), 488;
Received: 7 December 2018 / Revised: 25 February 2019 / Accepted: 27 February 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Polymer in Confinement)
PDF [2370 KB, uploaded 13 March 2019]


Polyelectrolytes constitute an important group of materials, used for such different purposes as the stabilization of emulsions and suspensions or oil recovery. They are also studied and utilized in the field of microfluidics. With respect to the latter, a part of the interest in polyelectrolytes inside microchannels stems from genetic analysis, considering that deoxyribonucleic acid (DNA) molecules are polyelectrolytes. This review summarizes the single-molecule experimental and molecular dynamics simulation-based studies of end-tethered polyelectrolytes, especially addressing their relaxation dynamics and deformation characteristics under various external forces in micro-confined environments. In most of these studies, DNA is considered as a model polyelectrolyte. Apart from summarizing the results obtained in that area, the most important experimental and simulation techniques are explained. View Full-Text
Keywords: polyelectrolyte; confinement; DNA; stretching; relaxation; Lattice Boltzmann; molecular dynamics polyelectrolyte; confinement; DNA; stretching; relaxation; Lattice Boltzmann; molecular dynamics

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Roy, T.; Szuttor, K.; Smiatek, J.; Holm, C.; Hardt, S. Conformation and Dynamics of Long-Chain End-Tethered Polymers in Microchannels. Polymers 2019, 11, 488.

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