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Polymers 2019, 11(3), 490;

Self-Healing Hydrogels with both LCST and UCST through Cross-Linking Induced Thermo-Response

Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
Medical College, Hebei University, Baoding 071002, China
Hebei TCM Formula Granule Technology Innovation Center & TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
Authors to whom correspondence should be addressed.
H.Z. and H.A. contributed equally to this work.
Received: 27 December 2018 / Revised: 24 February 2019 / Accepted: 8 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Hydrogels and Gels for Biomedical and Sustainable Applications)
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Self-healing hydrogels have drawngreat attention in the past decade since the self-healing property is one of the characteristics of living creatures. In this study, poly(acrylamide-stat-diacetone acrylamide) P(AM-stat-DAA) with a pendant ketone group was synthesized from easy accessible monomers, and thermo-responsive self-healing hydrogels were prepared through a series of diacylhydrazide compounds cross-linking without any additional stimulus. Although the copolymers do not show thermo-response, the hydrogels became thermo-responsive andboth the lower critical solution temperature (LCST) and upper critical solution temperature (UCST) varied with the composition of the copolymer and structure of cross-linkers. With a dynamic covalent bond connection, the hydrogel showed gel-sol-gel transition triggered by acidity, redox, and ketone to acylhydrazide group ratios. This is another interesting cross-linking induced thermo-responsive (CIT) hydrogel with different properties compared to PNIPAM-based thermo-responsive hydrogels. The self-healing hydrogel with CIT properties could have great potential for application in areas related to bioscience, life simulation, and temperature switching. View Full-Text
Keywords: P(AM-stat-DAA); self-healing hydrogel; cross-linking induced thermo-response P(AM-stat-DAA); self-healing hydrogel; cross-linking induced thermo-response

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhao, H.; An, H.; Xi, B.; Yang, Y.; Qin, J.; Wang, Y.; He, Y.; Wang, X. Self-Healing Hydrogels with both LCST and UCST through Cross-Linking Induced Thermo-Response. Polymers 2019, 11, 490.

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