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Polymers 2019, 11(3), 459; https://doi.org/10.3390/polym11030459

Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering

1
Department of Nanomaterials in Natural Science, Institute for Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
2
Institute of New Technologies and Applied Informatics, Faculty of Mechatronics, Informatics and Interdisciplinary Studies, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
3
Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
4
Department of Surface and Plasma Science, Faculty of Mathematics and Physics, Charles University, V Holešovičkách 2, 180 00 Prague 8, Czech Republic
5
Department of Chemistry, Faculty of Science, Humanities and Education, Technical University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 24 January 2019 / Revised: 1 March 2019 / Accepted: 6 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue Cyclodextrin-Containing Polymers)
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Abstract

Polypyrrole is one of the most investigated conductive polymers used for tissue engineering applications because of its advantageous properties and the ability to promote different cell types’ adhesion and proliferation. Together with β-cyclodextrin, which is capable of accommodating helpful biomolecules in its cavity, it would make a perfect couple for use as a scaffold for tissue engineering. Such scaffolds were prepared by the polymerisation of 6-(pyrrol-3-yl)hexanoic acid on polycaprolactone microfibres with subsequent attachment of β-cyclodextrin on the polypyrrole layer. The materials were deeply characterised by several physical and spectroscopic techniques. Testing of the cyclodextrin enriched composite scaffold revealed its better performance in in vitro experiments compared with pristine polycaprolactone or polypyrrole covered polycaprolactone scaffolds. View Full-Text
Keywords: cyclodextrin; pyrrole; polypyrrole; polycaprolactone; functionalisation; microfibres; tissue engineering; scaffold cyclodextrin; pyrrole; polypyrrole; polycaprolactone; functionalisation; microfibres; tissue engineering; scaffold
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lukášek, J.; Hauzerová, Š.; Havlíčková, K.; Strnadová, K.; Mašek, K.; Stuchlík, M.; Stibor, I.; Jenčová, V.; Řezanka, M. Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering. Polymers 2019, 11, 459.

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