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Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery

Cell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, Campus de A Coruña, 15071 A Coruña, Spain
Center of Experimental Orthopaedics, Saarland University Medical Center, D-66421 Homburg/Saar, Germany
Author to whom correspondence should be addressed.
Polymers 2019, 11(3), 514;
Received: 6 March 2019 / Revised: 15 March 2019 / Accepted: 17 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Cyclodextrin-Containing Polymers)
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Controlled delivery of gene transfer vectors is a powerful strategy to enhance the temporal and spatial presentation of therapeutic agents in a defined target. Hydrogels are adapted biomaterials for gene delivery capable of acting as a localized depot of genes while maintaining the long term local availability of DNA vectors at a specific location. Supramolecular hydrogels based on cyclodextrins (CDs) have attracted considerable attention as potential biomaterials in a broad range of drug delivery applications. Their unique characteristics of thixotropicity and low cytotoxicity due to their production under mild conditions make them potential candidates to form injectable delivery systems. This work aims to provide an overview of the use of CD-based polypseudorotaxane hydrogels as controlled gene delivery systems for different applications in regenerative medicine. View Full-Text
Keywords: supramolecular hydrogels; cyclodextrin-based polypseudorotaxane hydrogels; controlled gene delivery; nonviral vectors; viral vectors; gene transfer supramolecular hydrogels; cyclodextrin-based polypseudorotaxane hydrogels; controlled gene delivery; nonviral vectors; viral vectors; gene transfer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rey-Rico, A.; Cucchiarini, M. Supramolecular Cyclodextrin-Based Hydrogels for Controlled Gene Delivery. Polymers 2019, 11, 514.

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