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Polymers 2018, 10(10), 1133; https://doi.org/10.3390/polym10101133

Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

1
Department of Surgery, Chonnam National University Medical School, Gwangju 61469, Korea
2
Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun 58128, Korea
*
Authors to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 22 September 2018 / Accepted: 9 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Polymeric Micro/Nanoparticles for Bio-Medical Applications)
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Abstract

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment. View Full-Text
Keywords: hyaluronic acid (HA); nanoparticles (NPs); cancer; target therapy; chemotherapy; gene deliver; immunotherapy; combination cancer therapy hyaluronic acid (HA); nanoparticles (NPs); cancer; target therapy; chemotherapy; gene deliver; immunotherapy; combination cancer therapy
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Kim, J.H.; Moon, M.J.; Kim, D.Y.; Heo, S.H.; Jeong, Y.Y. Hyaluronic Acid-Based Nanomaterials for Cancer Therapy. Polymers 2018, 10, 1133.

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