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Polymers 2018, 10(10), 1132; https://doi.org/10.3390/polym10101132

Effect of Chemical Composition Variant and Oxygen Plasma Treatments on the Wettability of PLGA Thin Films, Synthesized by Direct Copolycondensation

Department of Chemical Engineering, Sungkyunkwan University, (16419) 2066 Seobu-Ro, Jangan-Gu, Suwon-Si, Gyeonggi-Do 16419, Korea
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Received: 7 September 2018 / Revised: 8 October 2018 / Accepted: 8 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Biodegradable Polymers for Environmental and Medical Applications)
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Abstract

The synthesis of high molecular weight poly (lactic-co-glycolic) acid (PLGA) copolymers via direct condensation copolymerization is itself a challenging task. Moreover, some of the characteristic properties of polylactide (PLA)-based biomaterials, such as brittleness, hydrophobicity, and longer degradation time, are not suitable for certain biomedical applications. However, such properties can be altered by the copolymerization of PLA with other biodegradable monomers, such as glycolic acid. A series of high molecular weight PLGAs were synthesized through the direct condensation copolymerization of lactic and glycolic acids, starting from 0 to 50 mol% of glycolic acid, and the wettability of its films was monitored as a function of the feed molar ratio. Copolymerization was performed in the presence of a bi-catalytic system using stannous chloride dihydrate and methanesulfonic acid (MSA). The viscosity average molecular weight of the resulting PLGA was in the range of 80k to 135k g/mol. The PLGA films were prepared using the solvent casting technique, and were treated with oxygen plasma for 2 min. The water contact angle of the PLGA films was determined before and after the oxygen plasma treatments, and it was observed that the wettability increased with an increase in the glycolic acid contents, however, the manifolds increased after 2 min of oxygen plasma treatments. View Full-Text
Keywords: direct esterification; PLGA; high molecular weight; copolymerization; wettability; hydrophobicity direct esterification; PLGA; high molecular weight; copolymerization; wettability; hydrophobicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ayyoob, M.; Kim, Y.J. Effect of Chemical Composition Variant and Oxygen Plasma Treatments on the Wettability of PLGA Thin Films, Synthesized by Direct Copolycondensation. Polymers 2018, 10, 1132.

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