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Polymers 2018, 10(12), 1357;

Contemporary Polymer-Based Nanoparticle Systems for Photothermal Therapy

Organogenesis, Surgical and Sports Medicine, Birmingham, AL 35216, USA
Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea
Authors to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 28 November 2018 / Accepted: 30 November 2018 / Published: 7 December 2018
(This article belongs to the Special Issue Polymeric Micro/Nanoparticles for Bio-Medical Applications)
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Current approaches for the treatment of cancer, such as chemotherapy, radiotherapy, immunotherapy, and surgery, are limited by various factors, such as inadvertent necrosis of healthy cells, immunological destruction, or secondary cancer development. Hyperthermic therapy is a promising strategy intended to mitigate many of the shortcomings associated with traditional therapeutic approaches. However, to utilize this approach effectively, it must be targeted to specific tumor sites to prevent adverse side effects. In this regard, photothermal therapy, using intravenously-administered nanoparticle materials capable of eliciting hyperthermic effects in combination with the precise application of light in the near-infrared spectrum, has shown promise. Many different materials have been proposed, including various inorganic materials such as Au, Ag, and Germanium, and C-based materials. Unfortunately, these materials are limited by concerns about accumulation and potential cytotoxicity. Polymer-based nanoparticle systems have been investigated to overcome limitations associated with traditional inorganic nanoparticle systems. Some of the materials that have been investigated for this purpose include polypyrrole, poly-(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), polydopamine, and polyaniline. The purpose of this review is to summarize these contemporary polymer-based nanoparticle technologies to acquire an understanding of their current applications and explore the potential for future improvements. View Full-Text
Keywords: photothermal therapy; polymeric nanoparticle; polyaniline; polypyrrole; polydopamine photothermal therapy; polymeric nanoparticle; polyaniline; polypyrrole; polydopamine

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Vines, J.B.; Lim, D.-J.; Park, H. Contemporary Polymer-Based Nanoparticle Systems for Photothermal Therapy. Polymers 2018, 10, 1357.

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