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Cancers 2016, 8(9), 78;

Aberrant Wnt Signaling in Leukemia

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Author to whom correspondence should be addressed.
Academic Editors: Renée van Amerongen and Walter Birchmeier
Received: 13 April 2016 / Revised: 25 July 2016 / Accepted: 22 August 2016 / Published: 26 August 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
Full-Text   |   PDF [1080 KB, uploaded 26 August 2016]   |  


The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling can contribute to leukemogenesis, both cell autonomously as well as by changes in the microenvironment. View Full-Text
Keywords: Wnt signaling; leukemic stem cell; leukemia; AML; CML; CLL; ALL; pathogenesis Wnt signaling; leukemic stem cell; leukemia; AML; CML; CLL; ALL; pathogenesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Staal, F.J.T.; Famili, F.; Garcia Perez, L.; Pike-Overzet, K. Aberrant Wnt Signaling in Leukemia. Cancers 2016, 8, 78.

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