Next Article in Journal
HPV Associated Head and Neck Cancer
Next Article in Special Issue
Aberrant Wnt Signaling in Leukemia
Previous Article in Journal / Special Issue
Developmental Drift and the Role of Wnt Signaling in Aging
Article Menu

Export Article

Open AccessReview
Cancers 2016, 8(8), 74;

The Role of the C-Clamp in Wnt-Related Colorectal Cancers

Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Author to whom correspondence should be addressed.
Academic Editors: Renée van Amerongen and Walter Birchmeier
Received: 9 May 2016 / Revised: 28 July 2016 / Accepted: 29 July 2016 / Published: 3 August 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
Full-Text   |   PDF [1545 KB, uploaded 3 August 2016]   |  


T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed. View Full-Text
Keywords: TCF/LEF; C-clamp; Wnt; β-catenin; colorectal cancer TCF/LEF; C-clamp; Wnt; β-catenin; colorectal cancer

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ravindranath, A.J.; Cadigan, K.M. The Role of the C-Clamp in Wnt-Related Colorectal Cancers. Cancers 2016, 8, 74.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top