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Clinical Utility and Limitation of Diagnostic Ability for Different Degrees of Dysplasia of Intraductal Papillary Mucinous Neoplasms of the Pancreas Using 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

1
Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima City 890-8520, Japan
2
Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima City 890-8520, Japan
3
Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima City 890-8520, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Atsushi Masamune
Cancers 2021, 13(18), 4633; https://doi.org/10.3390/cancers13184633
Received: 2 August 2021 / Revised: 31 August 2021 / Accepted: 14 September 2021 / Published: 15 September 2021
Elucidating risk factors for different degrees of dysplasia of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas is important in determining strategies for management. In this study, we searched for risk factors for different degrees of dysplasia of IPMNs. Our study indicated that there were no useful factors that significantly differentiated low-grade dysplasia and high-grade dysplasia; however, 18F-fluorodeoxyglucose–positron emission tomography/computed tomography is useful for differentiating between non-invasive and invasive IPMNs. Our results offer critical information that may determine surgical treatment strategies.
The diagnostic value of 18F-fluorodeoxyglucose (FDG) uptake in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas remains unclear. This study aimed to assess the role of FDG uptake in the diagnosis of different degrees of dysplasia of IPMNs. We retrospectively analyzed the following three points in 84 patients with IPMNs: (1) risk factors to predict high-grade dysplasia (HGD) and invasive carcinoma (INV); (2) the relationship between FDG uptake and glucose transporter 1 (GLUT-1) expression; and (3) the relationship between FDG uptake and the presence of mural nodules. The histopathological diagnosis was low-grade dysplasia (LGD) in 43 patients, HGD in 16, and INV in 25. The maximum standardized uptake value (SUV-max) was significantly higher in INV than in LGD/HGD (p < 0.0001, p = 0.0136). The sensitivity and specificity to discriminate INV from LGD/HGD were 80.0% and 86.2%, respectively, using the receiver operator characteristic curve, when the optimal cutoff score of SUV-max was set at 4.03. Those values were not different between HGD and LGD. More than half of HGD patients had low GLUT-1 expression. Taken together, FDG-PET/CT is useful in distinguishing between non-invasive and invasive IPMN. Our results offer critical information that may determine surgical treatment strategies. View Full-Text
Keywords: IPMN; FDG; PET; mural nodule; high-grade dysplasia; glucose transporter 1; GLUT-1 IPMN; FDG; PET; mural nodule; high-grade dysplasia; glucose transporter 1; GLUT-1
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MDPI and ACS Style

Hozaka, Y.; Kurahara, H.; Oi, H.; Idichi, T.; Yamasaki, Y.; Kawasaki, Y.; Tanoue, K.; Jinguji, M.; Nakajo, M.; Tani, A.; Nakajo, A.; Mataki, Y.; Fukukura, Y.; Noguchi, H.; Higashi, M.; Yoshiura, T.; Tanimoto, A.; Ohtsuka, T. Clinical Utility and Limitation of Diagnostic Ability for Different Degrees of Dysplasia of Intraductal Papillary Mucinous Neoplasms of the Pancreas Using 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography. Cancers 2021, 13, 4633. https://doi.org/10.3390/cancers13184633

AMA Style

Hozaka Y, Kurahara H, Oi H, Idichi T, Yamasaki Y, Kawasaki Y, Tanoue K, Jinguji M, Nakajo M, Tani A, Nakajo A, Mataki Y, Fukukura Y, Noguchi H, Higashi M, Yoshiura T, Tanimoto A, Ohtsuka T. Clinical Utility and Limitation of Diagnostic Ability for Different Degrees of Dysplasia of Intraductal Papillary Mucinous Neoplasms of the Pancreas Using 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography. Cancers. 2021; 13(18):4633. https://doi.org/10.3390/cancers13184633

Chicago/Turabian Style

Hozaka, Yuto, Hiroshi Kurahara, Hideyuki Oi, Tetsuya Idichi, Yoichi Yamasaki, Yota Kawasaki, Kiyonori Tanoue, Megumi Jinguji, Masatoyo Nakajo, Atsushi Tani, Akihiro Nakajo, Yuko Mataki, Yoshihiko Fukukura, Hirotsugu Noguchi, Michiyo Higashi, Takashi Yoshiura, Akihide Tanimoto, and Takao Ohtsuka. 2021. "Clinical Utility and Limitation of Diagnostic Ability for Different Degrees of Dysplasia of Intraductal Papillary Mucinous Neoplasms of the Pancreas Using 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography" Cancers 13, no. 18: 4633. https://doi.org/10.3390/cancers13184633

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