Next Article in Journal
Harnessing Carcinoma Cell Plasticity Mediated by TGF-β Signaling
Next Article in Special Issue
Molecular Pathways and Druggable Targets in Head and Neck Squamous Cell Carcinoma
Previous Article in Journal
Genomic Analysis of Response to Neoadjuvant Chemotherapy in Esophageal Adenocarcinoma
Previous Article in Special Issue
Longitudinal Circulating Tumor DNA Analysis in Blood and Saliva for Prediction of Response to Osimertinib and Disease Progression in EGFR-Mutant Lung Adenocarcinoma
Review

Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer

1
Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria
2
Laboratory of Molecular Pathology, University Hospital “St. Marina”, 9000 Varna, Bulgaria
3
Department of Medical Genetics, Molecular Medicine and Nutrigenomics, Medical University of Varna, 9000 Varna, Bulgaria
4
Clinic of Medical Oncology, Military Medical Academy, 1000 Sofia, Bulgaria
5
Clinic of Medical Oncology, Hospital Nadezhda, 1000 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Academic Editor: Anders Jakobsen
Cancers 2021, 13(14), 3395; https://doi.org/10.3390/cancers13143395
Received: 17 May 2021 / Revised: 13 June 2021 / Accepted: 2 July 2021 / Published: 6 July 2021
(This article belongs to the Collection Cancer Biomarkers)
Over the last few years, circular RNAs (circRNAs) are highly anticipated as new diagnostic and prognostic biomarkers. Our review aimed to present new data about circRNAs as targets in oncogenic axes to inhibit cancer activity. The review of circRNAs was made in the context of their oncogenic functions. Special attention was paid to circRNAs with clinical significance and to circRNAs with diagnostic and prognostic potential in colorectal cancer (CRC). Studies that evaluate the differential expression of circRNAs in the circulation between patients with CRC and healthy controls were considered. The review could be useful with its comprehensive information about known cicrRNAs with oncogenic function in CRC and with the questions it raises about the reliability of circRNAs as non-invasive biomarkers.
Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients. View Full-Text
Keywords: circular RNAs; circRNAs; colorectal cancer; oncogenic circular RNAs; circRNAs; colorectal cancer; oncogenic
Show Figures

Figure 1

MDPI and ACS Style

Radanova, M.; Mihaylova, G.; Nazifova-Tasinova, N.; Levkova, M.; Tasinov, O.; Ivanova, D.; Mihaylova, Z.; Donev, I. Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer. Cancers 2021, 13, 3395. https://doi.org/10.3390/cancers13143395

AMA Style

Radanova M, Mihaylova G, Nazifova-Tasinova N, Levkova M, Tasinov O, Ivanova D, Mihaylova Z, Donev I. Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer. Cancers. 2021; 13(14):3395. https://doi.org/10.3390/cancers13143395

Chicago/Turabian Style

Radanova, Maria, Galya Mihaylova, Neshe Nazifova-Tasinova, Mariya Levkova, Oskan Tasinov, Desislava Ivanova, Zhasmina Mihaylova, and Ivan Donev. 2021. "Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer" Cancers 13, no. 14: 3395. https://doi.org/10.3390/cancers13143395

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop