Next Article in Journal
Uncovering the Tumor Antigen Landscape: What to Know about the Discovery Process
Previous Article in Journal
Two-Dimensional Theranostic Nanomaterials in Cancer Treatment: State of the Art and Perspectives
Open AccessArticle

Prophylactic Central Lymph Node Dissection Improves Disease-Free Survival in Patients with Intermediate and High Risk Differentiated Thyroid Carcinoma: A Retrospective Analysis on 399 Patients

1
Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, Italy
2
Division of General and Oncologic Surgery, Department of Cardiothoracic Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1658; https://doi.org/10.3390/cancers12061658
Received: 19 May 2020 / Revised: 8 June 2020 / Accepted: 20 June 2020 / Published: 23 June 2020
The role of prophylactic central lymph node dissection (pCLND) in the treatment of differentiated thyroid cancer (DTC) is controversial and still a matter of debate. The primary outcome of our study was to assess whether pCLND is effective in reducing the incidence of recurrent disease, and the secondary goal was to estimate the incidence of postoperative complications in patients who underwent pCLND and to evaluate the prognostic value of occult node metastases. In this retrospective study, we included patients with preoperative diagnosis of DTC and clinically uninvolved lymph nodes (cN0). The patients were divided into two groups, depending on the surgical approach: total thyroidectomy alone (TT group) or total thyroidectomy and pCLND (pCLND group). Three hundred and ninety-nine patients were included in this study, 320 (80.2%) in the TT group and 79 (19.8%) in the pCLND group. There were no significant differences in morbidity among the two groups. Histopathological evaluation demonstrated a similar distribution of aggressive features, especially regarding multicentricity, extrathyroidal extension, and angioinvasivity between the two groups. Occult lymph node metastases were found in 20 (25.3%) patients in the pCLND group. Prophylactic CLND was effective in improving disease-free survival in patients with intermediate and high risk of disease recurrence (p = 0.0392); occult lymph node metastases resulted as a significant negative prognostic factor (p < 0.001). View Full-Text
Keywords: thyroid carcinoma; prophylactic central lymph node dissection; lymph node metastases thyroid carcinoma; prophylactic central lymph node dissection; lymph node metastases
Show Figures

Figure 1

MDPI and ACS Style

Medas, F.; Canu, G.L.; Cappellacci, F.; Anedda, G.; Conzo, G.; Erdas, E.; Calò, P.G. Prophylactic Central Lymph Node Dissection Improves Disease-Free Survival in Patients with Intermediate and High Risk Differentiated Thyroid Carcinoma: A Retrospective Analysis on 399 Patients. Cancers 2020, 12, 1658.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop