Next Article in Journal
MicroRNA-199b Downregulation Confers Resistance to 5-Fluorouracil Treatment and Predicts Poor Outcome and Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Patients
Previous Article in Journal
HERC Ubiquitin Ligases in Cancer
Open AccessArticle

Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer—A Population Based Study

1
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan
2
Department of Emergency Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei City 23561, Taiwan
3
Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan
4
Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan
5
School of Health Care Administration, College of Management, Taipei Medical University, Taipei City 110, Taiwan
6
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan
7
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City 100, Taiwan
8
Division of Nephrology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan
9
Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
10
TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei City 110, Taiwan
11
Department of Pharmacy, Faculty of Health Science, University of Muhammadiyah, Mataram 83115, Indonesia
12
Department of Internal Medicine, School of Medicine, College of Medicine, National Defense Medical Center, Taipei City 11490, Taiwan
13
Master Program in Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei City 110, Taiwan
14
Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei City 116, Taiwan
15
Department of Medical Research, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan
*
Authors to whom correspondence should be addressed.
Cancers 2020, 12(6), 1654; https://doi.org/10.3390/cancers12061654
Received: 2 April 2020 / Revised: 16 June 2020 / Accepted: 16 June 2020 / Published: 22 June 2020
The effect of comorbidities and the immune profiles of the kidney cancer microenvironment play a major role in patients’ prognosis and survival. Using the National Health Insurance Research Database (Taiwan), we identified patients aged >20 years with a first diagnosis of kidney cancer between 2005 and 2014. Differences in demographic characteristics and comorbidities were examined using the Pearson chi-squared test or the t test. The Cox regression model was used to construct the nomogram. RNA-seq data were applied from The Cancer Genome Atlas database, and correlations between immune metagenes and clinical characteristics were determined using a linear regression model. In this nationwide cohort study, including 5090 patients with kidney cancer, predictors in our prediction models included age, sex, chronic kidney disease, dialysis requirements, renal stones, cerebrovascular disease, and metastasis tumor. In the tumor tissue profiles, significant positive correlations between immune metagenes and clinical stage or overall survival were observed among Natural Killer (NK) cells (CD56−), CD4+ T-helper 2 (Th2) cells, and activated Dendritic Cell (aDC). A negative correlation was observed between expression level of Dendritic Cell (DC) and overall survival. Patients with kidney cancer exhibit high prevalence of comorbid disease, especially in older patients. Comorbid disease types exert unique effects, and a particular comorbidity can affect cancer mortality. Moreover, the expression of immune metagenes can be utilized as potentialbiomarkers especially for further study of molecular mechanisms as well as microenvironments in kidney cancer. View Full-Text
Keywords: kidney cancer; renal cell carcinoma; comorbidity; immune metagenes; survival kidney cancer; renal cell carcinoma; comorbidity; immune metagenes; survival
Show Figures

Figure 1

MDPI and ACS Style

Wong, C.-S.; Chen, T.-T.; Chang, W.-P.; Wong, H. .-C.; Wu, M.-Y.; Adikusuma, W.; Lin, Y.-F.; Chang, W.-C. Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer—A Population Based Study. Cancers 2020, 12, 1654.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop