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The Mechanical Microenvironment in Breast Cancer

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Program in Biochemistry and Molecular Biology, Department of Physiology, and Marlene and Stewart Greenebaum NCI Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore Street, Bressler Research Building, Rm 10-020 D, Baltimore, MD 21201, USA
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Department of Physiology and Marlene and Stewart Greenebaum NCI Cancer Center, University of Maryland School of Medicine, 655 W. Baltimore Street, Bressler Research Building, Rm 10-020 D, Baltimore, MD 21201, USA
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Authors to whom correspondence should be addressed.
Cancers 2020, 12(6), 1452; https://doi.org/10.3390/cancers12061452
Received: 15 April 2020 / Revised: 27 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Section Tumor Microenvironment)
Mechanotransduction is the interpretation of physical cues by cells through mechanosensation mechanisms that elegantly translate mechanical stimuli into biochemical signaling pathways. While mechanical stress and their resulting cellular responses occur in normal physiologic contexts, there are a variety of cancer-associated physical cues present in the tumor microenvironment that are pathological in breast cancer. Mechanistic in vitro data and in vivo evidence currently support three mechanical stressors as mechanical modifiers in breast cancer that will be the focus of this review: stiffness, interstitial fluid pressure, and solid stress. Increases in stiffness, interstitial fluid pressure, and solid stress are thought to promote malignant phenotypes in normal breast epithelial cells, as well as exacerbate malignant phenotypes in breast cancer cells. View Full-Text
Keywords: mechanosensation; mechanotransduction; mechanoresponsiveness; mechanobiology; breast cancer; stiffness; interstitial fluid pressure; solid stress mechanosensation; mechanotransduction; mechanoresponsiveness; mechanobiology; breast cancer; stiffness; interstitial fluid pressure; solid stress
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MDPI and ACS Style

Pratt, S.J.P.; Lee, R.M.; Martin, S.S. The Mechanical Microenvironment in Breast Cancer. Cancers 2020, 12, 1452. https://doi.org/10.3390/cancers12061452

AMA Style

Pratt SJP, Lee RM, Martin SS. The Mechanical Microenvironment in Breast Cancer. Cancers. 2020; 12(6):1452. https://doi.org/10.3390/cancers12061452

Chicago/Turabian Style

Pratt, Stephen J.P., Rachel M. Lee, and Stuart S. Martin 2020. "The Mechanical Microenvironment in Breast Cancer" Cancers 12, no. 6: 1452. https://doi.org/10.3390/cancers12061452

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