Next Article in Journal
Opportunities for Conventional and In Situ Cancer Vaccine Strategies and Combination with Immunotherapy for Gastrointestinal Cancers, A Review
Next Article in Special Issue
Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma
Previous Article in Journal
Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer
Previous Article in Special Issue
Pre-Analytical and Analytical Variables of Label-Independent Enrichment and Automated Detection of Circulating Tumor Cells in Cancer Patients
Review

The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review

1
Health Technology and Services Research Department, Technical Medical Centre, University of Twente, Hallenweg 5, 7522 NH Enschede, The Netherlands
2
Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
3
Respiratory Diseases, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands
4
Centre for Cancer Research and Centre for Health Policy, University of Melbourne, Parkville, VIC 3000, Australia
5
Peter MacCallum Cancer Centre, Parkville, VIC 3000, Australia
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(5), 1120; https://doi.org/10.3390/cancers12051120
Received: 24 March 2020 / Revised: 21 April 2020 / Accepted: 27 April 2020 / Published: 30 April 2020
(This article belongs to the Special Issue Liquid Biopsy in Cancer)
With the introduction of targeted therapies and immunotherapy, molecular diagnostics gained a more profound role in the management of non-small cell lung cancer (NSCLC). This study aimed to systematically search for studies reporting on the use of liquid biopsies (LB), the correlation between LBs and tissue biopsies, and finally the predictive value in the management of NSCLC. A systematic literature search was performed, including results published after 1 January 2014. Articles studying the predictive value or validity of a LB were included. The search (up to 1 September 2019) retrieved 1704 articles, 1323 articles were excluded after title and abstract screening. Remaining articles were assessed for eligibility by full-text review. After full-text review, 64 articles investigating the predictive value and 78 articles describing the validity were included. The majority of studies investigated the predictive value of LBs in relation to therapies targeting the epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) receptor (n = 38). Of studies describing the validity of a biomarker, 55 articles report on one or more EGFR mutations. Although a variety of blood-based biomarkers are currently under investigation, most studies evaluated the validity of LBs to determine EGFR mutation status and the subsequent targeting of EGFR tyrosine kinase inhibitors based on the mutation status found in LBs of NSCLC patients. View Full-Text
Keywords: liquid biopsy; non-small cell lung cancer; biomarkers liquid biopsy; non-small cell lung cancer; biomarkers
Show Figures

Figure 1

MDPI and ACS Style

van Delft, F.; Koffijberg, H.; Retèl, V.; Heuvel, M.v.d.; IJzerman, M. The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review. Cancers 2020, 12, 1120. https://doi.org/10.3390/cancers12051120

AMA Style

van Delft F, Koffijberg H, Retèl V, Heuvel Mvd, IJzerman M. The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review. Cancers. 2020; 12(5):1120. https://doi.org/10.3390/cancers12051120

Chicago/Turabian Style

van Delft, Frederik; Koffijberg, Hendrik; Retèl, Valesca; Heuvel, Michel v.d.; IJzerman, Maarten. 2020. "The Validity and Predictive Value of Blood-Based Biomarkers in Prediction of Response in the Treatment of Metastatic Non-Small Cell Lung Cancer: A Systematic Review" Cancers 12, no. 5: 1120. https://doi.org/10.3390/cancers12051120

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop