Next Article in Journal
Towards Physiologically and Tightly Regulated Vectored Antibody Therapies
Next Article in Special Issue
Radiomics Applications in Renal Tumor Assessment: A Comprehensive Review of the Literature
Previous Article in Journal
Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France)
Previous Article in Special Issue
Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
Article

Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers

1
Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei 230031, China
2
University of Science and Technology of China, Hefei 230026, China
3
Institute of Physical Science and Information Technology, School of Computer Science and Technology, Anhui University, Hefei 230039, China
4
Department of Ophthalmology & Visual Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China
*
Authors to whom correspondence should be addressed.
Cancers 2020, 12(4), 957; https://doi.org/10.3390/cancers12040957
Received: 4 March 2020 / Revised: 29 March 2020 / Accepted: 8 April 2020 / Published: 13 April 2020
(This article belongs to the Collection Application of Bioinformatics in Cancers)
Response to radiotherapy (RT) in cancers varies widely among patients. Therefore, it is very important to predict who will benefit from RT before clinical treatment. Consideration of the immune tumor microenvironment (TME) could provide novel insight into tumor treatment options. In this study, we investigated the link between immune infiltration status and clinical RT outcome in order to identify certain leukocyte subsets that could potentially influence the clinical RT benefit across cancers. By integrally analyzing the TCGA data across seven cancers, we identified complex associations between immune infiltration and patients RT outcomes. Besides, immune cells showed large differences in their populations in various cancers, and the most abundant cells were resting memory CD4 T cells. Additionally, the proportion of activated CD4 memory T cells and activated mast cells, albeit at low number, were closely related to RT overall survival in multiple cancers. Furthermore, a prognostic model for RT outcomes was established with good performance based on the immune infiltration status. Summarized, immune infiltration was found to be of significant clinical relevance to RT outcomes. These findings may help to shed light on the impact of tumor-associated immune cell infiltration on cancer RT outcomes, and identify biomarkers and therapeutic targets. View Full-Text
Keywords: pan-cancer; radiotherapy; immune infiltration; prognosis pan-cancer; radiotherapy; immune infiltration; prognosis
Show Figures

Figure 1

MDPI and ACS Style

Wen, P.; Gao, Y.; Chen, B.; Qi, X.; Hu, G.; Xu, A.; Xia, J.; Wu, L.; Lu, H.; Zhao, G. Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers. Cancers 2020, 12, 957. https://doi.org/10.3390/cancers12040957

AMA Style

Wen P, Gao Y, Chen B, Qi X, Hu G, Xu A, Xia J, Wu L, Lu H, Zhao G. Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers. Cancers. 2020; 12(4):957. https://doi.org/10.3390/cancers12040957

Chicago/Turabian Style

Wen, Pengbo, Yang Gao, Bin Chen, Xiaojing Qi, Guanshuo Hu, An Xu, Junfeng Xia, Lijun Wu, Huayi Lu, and Guoping Zhao. 2020. "Pan-Cancer Analysis of Radiotherapy Benefits and Immune Infiltration in Multiple Human Cancers" Cancers 12, no. 4: 957. https://doi.org/10.3390/cancers12040957

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop