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Glioblastoma: Pathogenesis and Current Status of Chemotherapy and Other Novel Treatments

Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI 53201, USA
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Author to whom correspondence should be addressed.
These authors contributed equally to the paper.
Cancers 2020, 12(4), 937; https://doi.org/10.3390/cancers12040937
Received: 11 March 2020 / Revised: 27 March 2020 / Accepted: 7 April 2020 / Published: 10 April 2020
(This article belongs to the Special Issue Tumors of the Central Nervous System: An Update)
Glioblastoma is one of the most common and detrimental forms of solid brain tumor, with over 10,000 new cases reported every year in the United States. Despite aggressive multimodal treatment approaches, the overall survival period is reported to be less than 15 months after diagnosis. A widely used approach for the treatment of glioblastoma is surgical removal of the tumor, followed by radiotherapy and chemotherapy. While there are several drugs available that are approved by the Food and Drug Administration (FDA), significant efforts have been made in recent years to develop new chemotherapeutic agents for the treatment of glioblastoma. This review describes the molecular targets and pathogenesis as well as the current progress in chemotherapeutic development and other novel therapies in the clinical setting for the treatment of glioblastoma. View Full-Text
Keywords: glioblastoma; molecular targets; pathogenesis; chemotherapy; novel therapy glioblastoma; molecular targets; pathogenesis; chemotherapy; novel therapy
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Rajaratnam, V.; Islam, M.M.; Yang, M.; Slaby, R.; Ramirez, H.M.; Mirza, S.P. Glioblastoma: Pathogenesis and Current Status of Chemotherapy and Other Novel Treatments. Cancers 2020, 12, 937.

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