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Article

Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients

1
Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan
2
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University School of Medicine, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
3
Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan
4
Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
5
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo 193-0998, Japan
6
Department of Head and Neck Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
7
Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(11), 3427; https://doi.org/10.3390/cancers12113427
Submission received: 20 October 2020 / Revised: 8 November 2020 / Accepted: 17 November 2020 / Published: 18 November 2020
(This article belongs to the Section Cancer Therapy)

Abstract

:

Simple Summary

No real-world, long-term outcomes of immunotherapy with nivolumab for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have yet been reported. Furthermore, the prognostic impact of the best overall response (BOR) of this therapy remains unclear. We conducted a multi-institutional cohort study of the long-term efficacy and safety of this therapy. We also evaluated the relationship between BOR and survival. Median follow-up time was 25.9 months. Median overall survival (OS) was 9.6 months, and two-year survival rate was 25.0%. Overall response rate was 18%, and disease control rate was 48%. For immune-related adverse events (irAEs), 38 irAEs were detected in 29 patients. The development of irAEs and better BOR were significantly associated with longer survival. These findings demonstrate the long-term efficacy and safety of nivolumab therapy for R/M SCCHN in a real-world setting. The magnitude of BOR and the development of irAEs might be useful surrogate markers of survival.

Abstract

No real-world, long-term outcomes of immunotherapy with nivolumab for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) have yet been reported. Furthermore, the prognostic impact of the best overall response (BOR) of this therapy remains unclear. We conducted a multi-institutional cohort study of the long-term efficacy and safety of this therapy and investigated prognostic factors associated with survival. Further, we evaluated the relationship between BOR and survival. Median follow-up time was 25.9 months. Median overall survival (OS) was 9.6 months, and two-year survival rate was 25.0%. Median progression-free survival (PFS) was 3.7 months, and two-year PFS rate was 19.6%. BOR was assessed as complete response (CR) in 6%, partial response (PR) in 13%, stable disease (SD) in 30%, and progressive disease (PD) in 52% of the patients. Overall response rate was 18%, and disease control rate was 48%. For immune-related adverse events (irAEs), 38 irAEs were detected in 29 patients. On multivariate analysis, the development of irAEs was significantly associated with better OS and PFS. Better BOR was significantly associated with longer OS and PFS. These findings demonstrate the long-term efficacy and safety of nivolumab therapy for R/M SCCHN in a real-world setting. The magnitude of BOR and the development of irAEs might be useful surrogate markers of survival.

Graphical Abstract

1. Introduction

The prognosis of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) is poor. Treatment commonly involves platinum-based regimens, but the rate of severe adverse events with these agents is high; these include renal dysfunction and bone marrow suppression, and most patients require hospitalization.
Nivolumab, an anti-programmed death 1 (PD-1) monoclonal antibody, is an immune checkpoint inhibitor (ICI). Efficacy of nivolumab in R/M SCCHN was demonstrated in a phase 3 trial (CheckMate 141 study) [1]. Nivolumab was approved for recurrent or metastatic head and neck cancer (R/M HNC) after platinum drug administration in Japan in March 2017. Further evidence of efficacy has since been obtained [2,3,4,5,6,7,8,9,10].
We previously conducted a multicenter study of 100 patients with R/M HNC, including 88 with R/M SCCHN, treated with nivolumab from April 2017 to August 2018 [11,12,13]. The median follow-up period was 6.7 months. Efficacy was comparable to that reported previously [1,3,14]. To the best of our knowledge, although more than three years have passed since the approval of nivolumab, the only publication which reported long-term efficacy and safety of nivolumab for R/M SCCHN was a two-year long-term survival update of CheckMate 141 [2], and no real-world outcomes have been reported. Real-world data reflect a wider patient/disease background than clinical trials and are considered to conform to actual clinical practice.
Studies in lung cancer and renal cell carcinoma indicate that response to ICIs is associated with survival, [15,16] suggesting that overall response may be a useful prognostic marker of nivolumab therapy. However, the prognostic impact of response in R/M SCCHN remains unclear.
Here, we report real-world, multicenter data for the long-term efficacy and safety of nivolumab in patients with R/M SCCHN. We also assessed survival according to the best overall response (BOR) to nivolumab.

2. Results

2.1. Patient Characteristics

Eighty-eight consecutive patients with R/M SCCHN were treated with nivolumab and enrolled during the study period. Patient characteristics have been described previously [12,13] and are summarized in Table 1. Unlike the CheckMate 141 study, our study included also patients with R/M SCCHN originating in the nasopharynx, paranasal sinus, salivary gland, and external auditory canal and included patients without platinum refractoriness. The median follow-up period was 25.9 months (range, 19.0–34.4 months). At data cutoff date, 14 patients remained on nivolumab therapy. Sixty-two patients discontinued nivolumab, most commonly due to disease progression. Nine patients discontinued due to immune-related adverse events (irAEs), while two and one discontinued due to other diseases (pneumonia and atypical mycobacteriosis) and prolonged disease control (>2 years), respectively. Thirty patients received chemotherapy after nivolumab.

2.2. Treatment Outcomes

Median overall survival (OS; interval between the date of first nivolumab administration and the date of death from any cause or the date of the last follow-up) was 9.6 months (95% confidence interval (95% CI), 8.4–12.0 months), and two-year survival rate was 25% (95% CI, 16–35%) (Figure 1a). Median progression-free survival (PFS; interval between the date of first nivolumab administration and the date of progressive disease (PD), the date of death from any cause, or the date of the last follow-up) was 3.7 months (95% CI, 2.6–4.6 months), and two-year PFS rate was 20% (95% CI, 12–29%) (Figure 1b).
BOR was available for all patients (Table 2). Complete response (CR) was achieved in 5 patients, partial response (PR) in 11, stable disease (SD) in 26, and PD in 46, giving an overall response rate (ORR: consisting of CR and PR) of 18% and a disease control rate (DCR: consisting of CR, PR, and SD) of 48%. Median duration from the first administration of nivolumab to the first observation of PR or CR was 80.5 days (range, 49–194 days).

2.3. Immune-Related Adverse Events

We summarized irAEs during the study period in Table 3. For all grades, 38 irAEs were detected in 29 patients, comprising interstitial lung disease (15%), thyroid dysfunction (9%), liver dysfunction (6%), and skin disorders (5%). For grade 3 and above, 10 irAEs occurred in 9 patients, including interstitial lung disease (6%), liver dysfunction (3%), skin disorder (1%), and enteritis (1%).
Median duration from the first administration of nivolumab to the first observation of irAEs was 75 days (range, 1–621 days). Nine patients discontinued nivolumab due to irAEs, including interstitial lung disease (six patients), liver dysfunction, enteritis, and skin disorder (one patient, respectively). We found that irAEs of grade 3 or more occurred at a median of 40 days (range, 1–266 days) from the first administration of nivolumab. Seven of 10 irAEs of grade 3 and greater were observed within 6 months, while one grade 5 interstitial lung disease occurred 266 days after the first administration of nivolumab.

2.4. Impact of Background Factors on Patient Survival

The impact of background factors on survival is shown in Table 4. Univariate analysis revealed that performance status (p < 0.001), platinum refractoriness (p = 0.06), and irAE (p = 0.065) were associated with OS. Multivariate analysis showed that performance status (p  <  0.001) and irAEs (p = 0.036) were significantly associated with OS. Likewise, performance status (p < 0.001), previous receipt of cetuximab (p = 0.042), platinum refractoriness (p = 0.028), and irAEs (p = 0.04) were associated with PFS by univariate analysis, while performance status (p  <  0.001) and development of irAEs (p = 0.023) were associated with PFS by multivariate analysis.
The median OS of patients with and without irAEs was 12.0 (95% CI 8.6–NA) and 9.1 (95% CI 6.4–10.9) months, respectively (p = 0.062, log-rank test). The median PFS of patients with and without irAE was 5.1 (95% CI 3.5–18.7) and 2.6 (95% CI 1.5–4.3) months, respectively (p = 0.037, log-rank test) (Table S1)

2.5. Survival According to Best Overall Response

Kaplan–Meier survival curves for OS and PFS for each magnitude of BOR are shown in Figure 2. The median and rate of one- and two-year OS and PFS for each magnitude of BOR are shown in Table 5. The median OS of patients with SD and PD was 11.1 (95% CI 8.6–20.7) and 6.4 (95% CI 3.3–9.0) months, respectively, while that of patients with CR/PR was not reached. Median PFS of SD and PD was 7.0 (95% CI 4.3–12.4) and 1.5 (95% CI 1.1–2.5) months, respectively, while that of patients with CR/PR was not reached. The rates of two-year OS of patients with CR/PR, SD, and PD were 94% (95% CI 63–99), 27% (95% CI 12–45), and 0% (95% CI, not evaluable), respectively. The rates of two-year PFS of patients with CR/PR, SD, and PD were 78% (95% CI 44–93), 17% (95% CI 5–34), and 0% (95% CI, not evaluable), respectively.
Patients whose BOR to nivolumab was PD had significantly shorter OS and PFS than those with CR/PR or SD (p  <  0.05, respectively).

3. Discussion

In this study, with a median follow-up period of 25.9 months, we demonstrated the long-term efficacy and acceptable rate of irAEs of immunotherapy with nivolumab in patients with R/M SCCHN. The magnitude of BOR was significantly associated with survival. To the best of our knowledge, this is the first study reporting real-world, long-term data on the efficacy and safety of nivolumab for R/M SCCHN and also the first to demonstrate an association between BOR to nivolumab and survival in these patients.
Limitations of this study include its retrospective design and relatively small sample size, albeit the fact that the study had a multicenter design. Accordingly, our findings might be unavoidably affected by selection bias.
Median OS (9.6 months) and median PFS (3.7 months) in our cohort were consistent with those of our previous analyses [11,12] and comparable with those in the CheckMate 141 study [1,2] (median OS of 7.7 months and median PFS of 2.0 months). Additionally, the two-year survival rate in our cohort (25%) was better than that in the CheckMate 141 study (17%). [2] ORR (18%) in our cohort was comparable to that in previous reports (13.3–26.1%), whereas DCR (48%) was better than that in the historical data (30.0–36.3%) [2,3,4,14]. This might have resulted from the fact that 28 patients in our cohort were without platinum refractoriness. Platinum refractoriness has been associated with worse prognosis in patients with R/M SCCHN [4,6]. Likewise, platinum refractoriness tended to be associated with shorter OS (hazard ratio (HR) 1.69, p = 0.06) and PFS (HR 1.80, p = 0.028) by univariate analysis in our cohort.
The incidence of irAEs (33%) in this study was similar to those in previous reports (35.9–38.1%) [4,5]. Severe irAEs are likely to occur within 6 months after the initiation of nivolumab treatment [2]; in fact, in this study, 70% of severe irAEs (Grade 3 or more) occurred within this period. In one case, however, Grade 5 interstitial lung disease occurred 8.7 months after the first administration of nivolumab, suggesting that attention to severe irAEs should continue for more than 6 months after nivolumab administration.
Interestingly, the development of irAEs has been associated with a better prognosis for nivolumab therapy [4,10,17,18,19], and our previous report showed consistent results in univariate analysis [11]. In this study, with an extended follow-up period, the development of irAE was significantly associated with better OS (HR 0.54, p = 0.036) and better PFS (HR 0.53, p = 0.023) on multivariate analysis.
Regarding the expression of programmed death-ligand 1 (PD-L1), its prognostic role for head and neck cancer has not been shown unlike for other types of carcinomas [20,21,22,23]. In R/M SCCHN patients treated with ICIs, whether overexpression of PD-L1 improves treatment outcome is still controversial [1,24]. In this study, patients with PD-L1-positive tumors tended to have longer OS and PFS, although the differences were not significant, which might be due to the fact that PD-L1 was evaluated in only 44 patients.
Nivolumab therapy is known for its unique patterns of response, such as pseudoprogression [25,26] and long-term benefit in responding patients [27,28]. The association between the magnitude of BOR and the prognosis of R/M SCCHN is therefore unclear. Consistent with other types of cancer [15,16], a higher magnitude of BOR was also associated with better survival in R/M HNSCC. Although BOR is not a predictor of efficacy before treatment, BOR might be a useful surrogate marker of survival. Whether similar results can be obtained with pembrolizumab, another anti-PD-1 antibody which is used in patients with R/M SCCHN [29], warrants investigation.

4. Materials and Methods

4.1. Patients

This study was a retrospective cohort study which enrolled patients with R/M HNC treated with nivolumab from May 2017 to August 2018 at four facilities in Japan: Kitasato University Hospital, Tokyo Medical University Hospital, Tokyo Medical University Hachioji Medical Center, and International University of Health and Welfare Mita Hospital. The medical charts of 88 consecutive patients treated with nivolumab were reviewed. All cases were histologically diagnosed as SCCHN in each facility and had been treated with platinum-based drugs before treatment with nivolumab. We excluded patients with non-SCC. Data cutoff date was 31 May, 2020. Information on patient characteristics, treatment modality, histological findings, and clinical outcomes was collected. Clinical stage was classified using the 8th edition of the TNM classification. Eastern Cooperative Oncology Group performance status (ECOG PS) was evaluated prior to administration of nivolumab. Platinum-refractory disease was defined as cancer with documented tumor progression during platinum-based treatment or recurrence within 6 months after the administration of platinum-based drugs.
The study was approved by the Institutional Ethics Review Board of each facility. Kitasato University Hospital (B20-119). Tokyo Medical University Hospital (T2020-0038). International University of Health and Welfare Mita Hospital (5-20-16). With regard to consent, patients could reject participation by opting out in response to an announcement on the institutions’ websites. This study was performed in accordance with the Declaration of Helsinki.

4.2. Treatment and Follow-up

Treatment and follow-up have been described in detail previously [11,12]. Nivolumab was administered at 3 mg/kg or a flat dose of 240 mg (after September 2018), the standard dose for the study period, every two weeks. After treatment initiation, CT or MRI imaging studies were performed every 4–6 weeks. Response was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Clinically obvious disease progression was judged as PD regardless of imaging results, and nivolumab treatment was discontinued. After nivolumab discontinuation, additional treatment with other agents was permitted.

4.3. Outcomes

Endpoints were OS, PFS, and BOR. ORR and DCR were also calculated.

4.4. Immune-Relate Adverse Events

We assessed irAEs according to CTCAE version 5.0 up to one month after the last administration of nivolumab.

4.5. Statistical Analysis

OS and PFS were estimated by the Kaplan–Meier product-limit method and tested by means of two-sided log-rank tests; p-values for comparison among the three groups of BOR (CR/PR, SD and PD) were corrected using the Bonferroni method. Participants lost to follow-up were censored on the day of last contact. Prognostic factors, including BOR for PFS and OS, were evaluated by estimating HRs and 95% CIs using univariate and multivariate Cox proportional hazards models.
Variables adjusted in the multivariate analyses included sex (male vs. female), age (<65 vs. ≥65 years), ECOG PS (0 vs. 1–2), smoking, and alcohol consumption (ever vs. never). Platinum refractoriness (yes vs. no) and irAEs (present vs. absent) had p-values of less than 0.1 on univariate analysis of OS and were also included in multivariate analysis. All statistical analyses were performed using EZR [30] version 1.51 (Saitama Medical Center, Jichi Medical University, Saitama, Japan), a graphical user interface, together with the R software environment for statistical computing and graphics (The R Foundation for Statistical Computing, Vienna, Austria); p-values of < 0.05 were considered statistically significant.

5. Conclusions

In this study, we demonstrated the long-term efficacy and safety of nivolumab therapy for R/M SCCHN in a real-world setting. Furthermore, we identified a significant association between the magnitude of BOR and patient survival and also confirmed a significant positive association between the development of irAEs and patient survival. We conclude that these factors might be useful surrogate markers of survival in patients with R/M SCCHN treated with nivolumab.

Supplementary Materials

The following are available online at https://www.mdpi.com/2072-6694/12/11/3427/s1, Table S1: Relationship between immune-related adverse events and survival.

Author Contributions

Conceptualization, T.M. (Takashi Matsuki), I.O. and C.F.; Data curation, T.M. (Takashi Matsuki), H.T. and T.Y.; Formal analysis, T.M. (Takashi Matsuki), M.S. and D.K.; Investigation, T.M. (Takashi Matsuki), T.K., T.O., H.S., T.I., K.T. (Kunihiko Tokashiki), K.T. (Kiyoaki Tsukahara), K.H., T.M. (Tatsuo Masubuchi) and K.M.; Methodology, Y.T. and G.O.; Supervision, K.T. (Kiyoaki Tsukahara), K.M. and T.Y.; Writing—Original draft, T.M. (Takashi Matsuki); Writing—Review and editing, T.M. (Takashi Matsuki), I.O., C.F., H.T., T.K., T.O., H.S., T.I., K.T. (Kunihiko Tokashiki), K.T. (Kiyoaki Tsukahara), K.H., T.M. (Tatsuo Masubuchi), Y.T., K.M., G.O., M.S., D.K. and T.Y. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Acknowledgments

K. Tsukahara has received grant support from Ono Pharmaceutical Co., Ltd.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Ferris, R.L.; Blumenschein, G., Jr.; Fayette, J.; Guigay, J.; Colevas, A.D.; Licitra, L.; Harrington, K.; Kasper, S.; Vokes, E.E.; Even, C.; et al. Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck. N. Engl. J. Med. 2016, 375, 1856–1867. [Google Scholar] [CrossRef] [PubMed]
  2. Ferris, R.L.; Blumenschein, G., Jr.; Fayette, J.; Guigay, J.; Colevas, A.D.; Licitra, L.; Harrington, K.J.; Kasper, S.; Vokes, E.E.; Even, C.; et al. Nivolumab vs investigator’s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression. Oral Oncol. 2018, 81, 45–51. [Google Scholar] [CrossRef] [PubMed]
  3. Kiyota, N.; Hasegawa, Y.; Takahashi, S.; Yokota, T.; Yen, C.J.; Iwae, S.; Shimizu, Y.; Hong, R.L.; Goto, M.; Kang, J.H.; et al. A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator’s choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of Asian patients versus the global population in checkmate 141. Oral Oncol. 2017, 73, 138–146. [Google Scholar] [CrossRef]
  4. Hori, R.; Shinohara, S.; Kojima, T.; Kagoshima, H.; Kitamura, M.; Tateya, I.; Tamaki, H.; Kumabe, Y.; Asato, R.; Harada, H.; et al. Real-World Outcomes and Prognostic Factors in Patients Receiving Nivolumab Therapy for Recurrent or Metastatic Head and Neck Carcinoma. Cancers 2019, 11, 1317. [Google Scholar] [CrossRef] [Green Version]
  5. Ueki, Y.; Takahashi, T.; Ota, H.; Shodo, R.; Yamazaki, K.; Horii, A. Predicting the treatment outcome of nivolumab in recurrent or metastatic head and neck squamous cell carcinoma: Prognostic value of combined performance status and modified Glasgow prognostic score. Eur. Arch. Otorhinolaryngol. 2020, 277, 2341–2347. [Google Scholar] [CrossRef] [PubMed]
  6. Inoue, H.; Yokota, T.; Hamauchi, S.; Onozawa, Y.; Kawakami, T.; Shirasu, H.; Notsu, A.; Yasui, H.; Onitsuka, T. Pre-treatment tumor size impacts on response to nivolumab in head and neck squamous cell carcinoma. Auris Nasus Larynx 2020, 47, 650–657. [Google Scholar] [CrossRef] [PubMed]
  7. Suzuki, C.; Kiyota, N.; Imamura, Y.; Rikitake, J.; Sai, S.; Koyama, T.; Hyogo, Y.; Nagatani, Y.; Funakoshi, Y.; Toyoda, M.; et al. Effect of tumor burden and growth rate on treatment outcomes of nivolumab in head and neck cancer. Int. J. Clin. Oncol. 2020, 25, 1270–1277. [Google Scholar] [CrossRef] [PubMed]
  8. Niwa, K.; Kawakita, D.; Nagao, T.; Takahashi, H.; Saotome, T.; Okazaki, M.; Yamazaki, K.; Okamoto, I.; Hirai, H.; Saigusa, N.; et al. Multicentre, retrospective study of the efficacy and safety of nivolumab for recurrent and metastatic salivary gland carcinoma. Sci. Rep. 2020, 10, 16988. [Google Scholar] [CrossRef] [PubMed]
  9. Fushimi, C.; Okamoto, I.; Matsuki, T.; Masubuchi, T.; Okada, T.; Sato, H.; Tsukahara, K.; Kondo, T.; Yamashita, T.; Hanyu, K.; et al. Salvage Chemotherapy After Nivolumab for Recurrent or Metastatic Head and Neck Carcinoma. Anticancer Res. 2020, 40, 5277–5283. [Google Scholar] [CrossRef]
  10. Matsuo, M.; Yasumatsu, R.; Masuda, M.; Toh, S.; Wakasaki, T.; Hashimoto, K.; Taura, M.; Uchi, R.; Nakagawa, T. Relationship between immune-related adverse events and the long-term outcomes in recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab. Oral Oncol. 2020, 101, 104525. [Google Scholar] [CrossRef]
  11. Okamoto, I.; Sato, H.; Kondo, T.; Koyama, N.; Fushimi, C.; Okada, T.; Miura, K.; Matsuki, T.; Yamashita, T.; Omura, G.; et al. Efficacy and safety of nivolumab in 100 patients with recurrent or metastatic head and neck cancer—A retrospective multicentre study. Acta Otolaryngol 2019, 139, 918–925. [Google Scholar] [CrossRef] [PubMed]
  12. Matsuki, T.; Okamoto, I.; Fushimi, C.; Sawabe, M.; Kawakita, D.; Sato, H.; Tsukahara, K.; Kondo, T.; Okada, T.; Tada, Y.; et al. Hematological predictive markers for recurrent or metastatic squamous cell carcinomas of the head and neck treated with nivolumab: A multicenter study of 88 patients. Cancer Med. 2020, 9, 5015–5024. [Google Scholar] [CrossRef] [PubMed]
  13. Kondo, T.; Okamoto, I.; Sato, H.; Koyama, N.; Fushimi, C.; Okada, T.; Masubuchi, T.; Miura, K.; Matsuki, T.; Yamashita, T.; et al. Age-based efficacy and safety of nivolumab for recurrent or metastatic head and neck squamous cell carcinoma: A multicenter retrospective study. Asia Pac. J. Clin. Oncol. 2020. [Google Scholar] [CrossRef]
  14. Nishikawa, D.; Suzuki, H.; Koide, Y.; Beppu, S.; Kadowaki, S.; Sone, M.; Hanai, N. Prognostic Markers in Head and Neck Cancer Patients Treated with Nivolumab. Cancers 2018, 10, 466. [Google Scholar] [CrossRef] [Green Version]
  15. Antonia, S.J.; Borghaei, H.; Ramalingam, S.S.; Horn, L.; De Castro Carpeño, J.; Pluzanski, A.; Burgio, M.A.; Garassino, M.; Chow, L.Q.M.; Gettinger, S.; et al. Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: A pooled analysis. Lancet Oncol. 2019, 20, 1395–1408. [Google Scholar] [CrossRef]
  16. Ishihara, H.; Takagi, T.; Kondo, T.; Tachibana, H.; Fukuda, H.; Yoshida, K.; Iizuka, J.; Kobayashi, H.; Okumi, M.; Ishida, H.; et al. Correlation between the magnitude of best tumor response and patient survival in nivolumab therapy for metastatic renal cell carcinoma. Med. Oncol. 2019, 36, 35. [Google Scholar] [CrossRef] [PubMed]
  17. Rogado, J.; Sánchez-Torres, J.M.; Romero-Laorden, N.; Ballesteros, A.I.; Pacheco-Barcia, V.; Ramos-Leví, A.; Arranz, R.; Lorenzo, A.; Gullón, P.; Donnay, O.; et al. Immune-related adverse events predict the therapeutic efficacy of anti-PD-1 antibodies in cancer patients. Eur. J. Cancer 2019, 109, 21–27. [Google Scholar] [CrossRef]
  18. Teraoka, S.; Fujimoto, D.; Morimoto, T.; Kawachi, H.; Ito, M.; Sato, Y.; Nagata, K.; Nakagawa, A.; Otsuka, K.; Uehara, K.; et al. Early Immune-Related Adverse Events and Association with Outcome in Advanced Non-Small Cell Lung Cancer Patients Treated with Nivolumab: A Prospective Cohort Study. J. Thorac. Oncol. 2017, 12, 1798–1805. [Google Scholar] [CrossRef]
  19. Haratani, K.; Hayashi, H.; Chiba, Y.; Kudo, K.; Yonesaka, K.; Kato, R.; Kaneda, H.; Hasegawa, Y.; Tanaka, K.; Takeda, M.; et al. Association of Immune-Related Adverse Events With Nivolumab Efficacy in Non-Small-Cell Lung Cancer. JAMA Oncol. 2018, 4, 374–378. [Google Scholar] [CrossRef]
  20. Ma, G.; Deng, Y.; Jiang, H.; Li, W.; Wu, Q.; Zhou, Q. The prognostic role of programmed cell death-ligand 1 expression in non-small cell lung cancer patients: An updated meta-analysis. Clin. Chim. Acta 2018, 482, 101–107. [Google Scholar] [CrossRef]
  21. Wang, Z.; Peng, S.; Xie, H.; Guo, L.; Cai, Q.; Shang, Z.; Jiang, N.; Niu, Y. Prognostic and clinicopathological significance of PD-L1 in patients with renal cell carcinoma: A meta-analysis based on 1863 individuals. Clin. Exp. Med. 2018, 18, 165–175. [Google Scholar] [CrossRef] [PubMed]
  22. Zhang, M.; Sun, H.; Zhao, S.; Wang, Y.; Pu, H.; Wang, Y.; Zhang, Q. Expression of PD-L1 and prognosis in breast cancer: A meta-analysis. Oncotarget 2017, 8, 31347–31354. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  23. Troiano, G.; Caponio, V.C.A.; Zhurakivska, K.; Arena, C.; Pannone, G.; Mascitti, M.; Santarelli, A.; Lo Muzio, L. High PD-L1 expression in the tumour cells did not correlate with poor prognosis of patients suffering for oral squamous cells carcinoma: A meta-analysis of the literature. Cell Prolif. 2019, 52, e12537. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  24. Jia, Y.Q.; Yang, B.; Wen, L.L.; Mu, W.X.; Wang, Z.; Cheng, B. Prognostic value of immune checkpoint molecules in head and neck cancer: A meta-analysis. Aging 2019, 11, 501–522. [Google Scholar] [CrossRef] [PubMed]
  25. Queirolo, P.; Spagnolo, F. Atypical responses in patients with advanced melanoma, lung cancer, renal-cell carcinoma and other solid tumors treated with anti-PD-1 drugs: A systematic review. Cancer Treat. Rev. 2017, 59, 71–78. [Google Scholar] [CrossRef]
  26. Lauber, K.; Dunn, L. Immunotherapy Mythbusters in Head and Neck Cancer: The Abscopal Effect and Pseudoprogression. Am. Soc. Clin. Oncol. Educ. Book 2019, 39, 352–363. [Google Scholar] [CrossRef]
  27. Ferrara, R.; Pilotto, S.; Caccese, M.; Grizzi, G.; Sperduti, I.; Giannarelli, D.; Milella, M.; Besse, B.; Tortora, G.; Bria, E. Do immune checkpoint inhibitors need new studies methodology? J. Thorac. Dis. 2018, 10, S1564–S1580. [Google Scholar] [CrossRef]
  28. Vivot, A.; Créquit, P.; Porcher, R. Use of Late-Life Expectancy for Assessing the Long-Term Benefit of Immune Checkpoint Inhibitors. J. Natl. Cancer Inst. 2019, 111, 519–521. [Google Scholar] [CrossRef]
  29. Burtness, B.; Harrington, K.J.; Greil, R.; Soulières, D.; Tahara, M.; de Castro, G., Jr.; Psyrri, A.; Basté, N.; Neupane, P.; Bratland, Å.; et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study. Lancet 2019, 394, 1915–1928. [Google Scholar] [CrossRef]
  30. Kanda, Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013, 48, 452–458. [Google Scholar] [CrossRef] [Green Version]
Figure 1. Kaplan–Meier survival curves of (a) overall survival (OS) and (b) progression-free survival (PFS) on median follow-up time of 25.9 months. (a) Median OS: 9.6 months (95% CI, 8.4–12.0), one-year OS: 39.8% (95% CI, 29.6–49.8), and two-year OS: 25.0% (95% CI, 16.4–34.7). (b) Median PFS: 3.7 months (95% CI, 2.6–4.6), one-year PFS: 26.0% (95% CI, 17.4–35.5), and two-year PFS: 19.6% (95% CI, 11.9–28.7).
Figure 1. Kaplan–Meier survival curves of (a) overall survival (OS) and (b) progression-free survival (PFS) on median follow-up time of 25.9 months. (a) Median OS: 9.6 months (95% CI, 8.4–12.0), one-year OS: 39.8% (95% CI, 29.6–49.8), and two-year OS: 25.0% (95% CI, 16.4–34.7). (b) Median PFS: 3.7 months (95% CI, 2.6–4.6), one-year PFS: 26.0% (95% CI, 17.4–35.5), and two-year PFS: 19.6% (95% CI, 11.9–28.7).
Cancers 12 03427 g001
Figure 2. Kaplan–Meier survival curves of each best overall response for OS (a) and PFS (b). A higher magnitude of best overall response was significantly associated with longer (a) OS and (b) PFS (both, p < 0.001).
Figure 2. Kaplan–Meier survival curves of each best overall response for OS (a) and PFS (b). A higher magnitude of best overall response was significantly associated with longer (a) OS and (b) PFS (both, p < 0.001).
Cancers 12 03427 g002
Table 1. Patient characteristics at baseline.
Table 1. Patient characteristics at baseline.
CharacteristicN = 88(%)
Sex
Male71(81)
Female17(19)
Age
<65 years39(44)
≥65 years49(56)
ECOG performance status
059(67)
124(27)
≥25(6)
Primary site
Nasopharynx10(11)
Oropharynx19(22)
p16-positive8(9)
Hypopharynx21(24)
Larynx10(11)
Oral cavity17(19)
Paranasal sinus6(7)
Salivary gland2(2)
External auditory canal3(3)
Histology
Squamous cell carcinoma88(100)
Smoking
Ever61(69)
Never26(30)
Unknown1(1)
Alcohol
Ever69(78)
Never17(19)
Unknown2(2)
Distant metastasis
Present26(30)
Absent52(59)
Previous exposure to cetuximab
Yes30(34)
No58(66)
Platinum refractoriness a
Yes28(32)
No60(68)
Previous radiotherapy
Yes17(19)
No71(81)
Previous number of chemotherapy regimens b
137(42)
235(40)
≥316(18)
PD-L1 expression (0)
Positive (≥1%)37(42)
Negative (<1%)7(8)
Unknown44(50)
Institution (0)
TMU41(47)
IUHW24(27)
KU15(17)
TMU/HMC8(9)
a Time from the final administration of platinum-based drugs until progressive disease was less than 6 months. b The category “previous number of chemotherapy regimens” includes all the chemotherapy given in the treatment of the SCCHN. Abbreviations: ECOG, Eastern Cooperative Oncology Group; TMU, Tokyo Medical University; IUWH, International University of Health and Welfare Mita Hospital; KU, Kitasato University; and TMU/HMC, Tokyo Medical University Hachioji Medical Center. Median follow-up time was 25.9 months.
Table 2. Best overall response.
Table 2. Best overall response.
Best Overall ResponseN = 88(%)
Complete response (CR)5(6)
Partial response (PR)11(13)
Stable disease (SD)26(30)
Progressive disease (PD)46(52)
Response rate (CR + PR)16(18)
Disease control rate (CR + PR + SD)42(48)
Abbreviations: CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.
Table 3. Immune-related adverse events.
Table 3. Immune-related adverse events.
Immune-Related Adverse EventsAny GradeGrade 3–5
Interstitial lung disease135
Thyroid dysfunction80
Liver dysfunction53
Skin disorders41
Enteritis11
Adrenal insufficiency10
Infusion reactions10
Myositis10
Parathyroid dysfunction10
Pituitary dysfunction10
Renal dysfunction10
Rheumatoid arthritis10
Total3810
(29 patients)(9 patients)
Table 4. Univariate and multivariate analyses of background factors for overall survival and progression-free survival.
Table 4. Univariate and multivariate analyses of background factors for overall survival and progression-free survival.
Overall SurvivalProgression-Free Survival
Background FactorsCrudeAdjusted aCrudeAdjusted a
HR (95% CI)p-ValueHR (95% CI)p-ValueHR (95% CI)p-ValueHR (95% CI)p-Value
Sex
Male (Ref. Female)1.03 (0.54–1.98)0.9220.54 (0.22–1.34)0.1851.19 (0.64–2.23)0.5810.64 (0.28–1.45)0.281
Age
≥65 years (Ref. < 65 years)1.37 (0.83–2.24)0.2161.27 (0.76–2.14)0.3620.97 (0.61–1.56)0.9140.79 (0.48–1.30)0.354
ECOG performance status
2–3 (Ref. 0–1)16.91 (5.69–50.32)<0.00120.07 (6.35–63.39)<0.0016.00 (2.31–15.53)<0.0017.87 (2.77–22.35)<0.001
Smoking
Ever (Ref. Never)1.17 (0.67–2.04)0.5830.86 (0.42–1.75)0.6691.16 (0.69–1.94)0.5870.86 (0.45–1.66)0.660
Alcohol consumption
Ever (Ref. Never)1.51 (0.77–2.98)0.2301.64 (0.67–4.03)0.2781.61 (0.84–3.08)0.1491.60 (0.71–3.60)0.257
Distant metastasis
Present (Ref. Absent)0.94 (0.57–1.55)0.818 0.95 (0.59–1.53)0.844
Previous exposure to cetuximab
Yes (Ref. No)1.43 (0.84–2.45)0.188 1.71 (1.02–2.88)0.042
Platinum refractoriness
Yes (Ref. No)1.69 (0.98–2.91)0.0601.55 (0.80–3.01)0.1961.80 (1.07–3.05)0.0281.78 (0.96–3.30)0.067
Previous radiotherapy
Yes (Ref. No)1.05 (0.56–1.96)0.883 0.83 (0.46–1.50)0.539
Previous number of chemotherapy regimens
two or more (Ref. 1)1.05 (0.63–1.73)0.860 1.12 (0.70–1.80)0.640
PD-L1 expression
Positive (Ref. Negative)0.58 (0.25–1.35)0.203 0.50 (0.21–1.19)0.117
p16 expression
Positive (Ref. Negative or Unknown)0.66 (0.28–1.53)0.332 0.76 (0.35–1.66)0.490
Immune-related adverse events
Yes (Ref. No)0.60 (0.35–1.03)0.0650.54 (0.31–0.96)0.0360.59 (0.35–0.98)0.0400.53 (0.31–0.92)0.023
a Adjusted by sex, age, performance status, smoking, alcohol consumption, platinum refractoriness, and immune-related adverse events. Abbreviations: HR, hazard ratio; CI, confidence interval.
Table 5. Relationship between best overall response and survival.
Table 5. Relationship between best overall response and survival.
Overall Survival
Crude
N = 88(%)median (months)(95% CI)1-year OS (%)(95% CI)2-year OS (%)(95% CI)HR(95% CI)p-value
CR/PR16(18)NR 94(63–99)94(63–99)0.02(0.003–0.15)<0.001
SD26(30)11.1(8.6–20.7)46(27–64)27(12–45)0.37(0.21–0.65)0.001
PD46(52)6.4(3.3–9.0)17(8–30)0(NA-NA)1 (reference)
Progression-Free Survival
Crude
N = 88(%)median (months)(95% CI)1-year PFS (%)(95% CI)2-year PFS (%)(95% CI)HR(95% CI)p-value
CR/PR16(18)NR(22.1-NA)88(59–97)78(44–93)0.02(0.005–0.06)<0.001
SD26(30)7.0(4.3–12.4)34(16–52)17(5–34)0.10(0.05–0.22)<0.001
PD46(52)1.5(1.1–2.5)NA(NA-NA)0(NA-NA)1 (reference)
Abbreviations: NA, not available; NR, not reached.
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Matsuki, T.; Okamoto, I.; Fushimi, C.; Takahashi, H.; Okada, T.; Kondo, T.; Sato, H.; Ito, T.; Tokashiki, K.; Tsukahara, K.; et al. Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients. Cancers 2020, 12, 3427. https://doi.org/10.3390/cancers12113427

AMA Style

Matsuki T, Okamoto I, Fushimi C, Takahashi H, Okada T, Kondo T, Sato H, Ito T, Tokashiki K, Tsukahara K, et al. Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients. Cancers. 2020; 12(11):3427. https://doi.org/10.3390/cancers12113427

Chicago/Turabian Style

Matsuki, Takashi, Isaku Okamoto, Chihiro Fushimi, Hideaki Takahashi, Takuro Okada, Takahito Kondo, Hiroki Sato, Tatsuya Ito, Kunihiko Tokashiki, Kiyoaki Tsukahara, and et al. 2020. "Real-World, Long-Term Outcomes of Nivolumab Therapy for Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck and Impact of the Magnitude of Best Overall Response: A Retrospective Multicenter Study of 88 Patients" Cancers 12, no. 11: 3427. https://doi.org/10.3390/cancers12113427

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