Next Article in Journal
Role of the Exosome in Ovarian Cancer Progression and Its Potential as a Therapeutic Target
Previous Article in Journal
KRAS-Driven Lung Adenocarcinoma and B Cell Infiltration: Novel Insights for Immunotherapy
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle

BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work

1
Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy
2
Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, 60126 Ancona, Italy
3
Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, Italy
4
Department of Community Medicine, University of Connecticut Health Center, Farmington, CT 06032, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(8), 1146; https://doi.org/10.3390/cancers11081146
Received: 10 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019
(This article belongs to the Special Issue 3rd Etnean Occupational Medicine Workshop—Breast Cancer and Work)
  |  
PDF [1464 KB, uploaded 21 August 2019]
  |  

Abstract

BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock alterations and with a higher risk of breast cancer. The aim of this study was to investigate the variability of expression of BRCA genes through the day in healthy subjects and to measure BRCA expression levels in shift workers. The study was approached in two ways. First, we examined diurnal variation of BRCA1 and BRCA2 genes in lymphocytes of 15 volunteers over a 24-hour period. Second, we measured the expression of these genes in lymphocytes from a group of shift and daytime workers. The change in 24-hour expression levels of BRCA1 and BRCA2 genes was statistically significant, decreasing from the peak at midday to the lowest level at midnight. Lower levels for both genes were found in shift workers compared to daytime workers. Diurnal variability of BRCA1 and BRCA2 expression suggests a relation of DNA double-strand break repair system with biological clock. Lower levels of BRCA1 and BRCA2 found in shift workers may be one of the potential factors related to the higher risk of breast cancer. View Full-Text
Keywords: BRCA1 gene; BRCA2 gene; DNA damage; DNA repair; breast cancer; biological clocks; shift work schedule; night shift work; chronobiology disorders; desynchronization of circadian rhythms BRCA1 gene; BRCA2 gene; DNA damage; DNA repair; breast cancer; biological clocks; shift work schedule; night shift work; chronobiology disorders; desynchronization of circadian rhythms
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Bracci, M.; Ciarapica, V.; Eléxpuru Zabaleta, M.; Tartaglione, M.F.; Pirozzi, S.; Giuliani, L.; Piva, F.; Valentino, M.; Ledda, C.; Rapisarda, V.; Stevens, R.G.; Santarelli, L. BRCA1 and BRCA2 Gene Expression: Diurnal Variability and Influence of Shift Work. Cancers 2019, 11, 1146.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top