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Developing Picornaviruses for Cancer Therapy

1
Department of Microbiology and Immunology, University of Otago, Dunedin 9016, New Zealand
2
Otago Micro and Nano Imaging, University of Otago, Dunedin 9016, New Zealand
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(5), 685; https://doi.org/10.3390/cancers11050685
Received: 4 April 2019 / Revised: 2 May 2019 / Accepted: 8 May 2019 / Published: 16 May 2019
PDF [1605 KB, uploaded 16 May 2019]

Abstract

Oncolytic viruses (OVs) form a group of novel anticancer therapeutic agents which selectively infect and lyse cancer cells. Members of several viral families, including Picornaviridae, have been shown to have anticancer activity. Picornaviruses are small icosahedral non-enveloped, positive-sense, single-stranded RNA viruses infecting a wide range of hosts. They possess several advantages for development for cancer therapy: Their genomes do not integrate into host chromosomes, do not encode oncogenes, and are easily manipulated as cDNA. This review focuses on the picornaviruses investigated for anticancer potential and the mechanisms that underpin this specificity.
Keywords: picornavirus; oncolytic virotherapy; poliovirus; coxsackievirus; senecavirus picornavirus; oncolytic virotherapy; poliovirus; coxsackievirus; senecavirus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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McCarthy, C.; Jayawardena, N.; Burga, L.N.; Bostina, M. Developing Picornaviruses for Cancer Therapy. Cancers 2019, 11, 685.

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