Next Article in Journal
Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition
Next Article in Special Issue
PTEN Hamartoma Tumor Syndrome: A Clinical Overview
Previous Article in Journal
Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy
Previous Article in Special Issue
PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 11
Issue 5
10.3390/cancers11050629
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response

by
Alberto M. Martelli
1,
Francesca Paganelli
1,
Antonietta Fazio
1,
Chiara Bazzichetto
2,
Fabiana Conciatori
2 and
James A. McCubrey
3,*
1
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
2
Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy
3
Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(5), 629; https://doi.org/10.3390/cancers11050629
Submission received: 22 March 2019 / Revised: 16 April 2019 / Accepted: 4 May 2019 / Published: 6 May 2019
(This article belongs to the Special Issue PTEN: A Multifaceted Tumor Suppressor)
Browse Figures
Versions Notes

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer that comprises 10–15% of pediatric and ~25% of adult ALL cases. Although the curative rates have significantly improved over the past 10 years, especially in pediatric patients, T-ALL remains a challenge from a therapeutic point of view, due to the high number of early relapses that are for the most part resistant to further treatment. Considerable advances in the understanding of the genes, signaling networks, and mechanisms that play crucial roles in the pathobiology of T-ALL have led to the identification of the key drivers of the disease, thereby paving the way for new therapeutic approaches. PTEN is critical to prevent the malignant transformation of T-cells. However, its expression and functions are altered in human T-ALL. PTEN is frequently deleted or mutated, while PTEN protein is often phosphorylated and functionally inactivated by casein kinase 2. Different murine knockout models recapitulating the development of T-ALL have demonstrated that PTEN abnormalities are at the hub of an intricate oncogenic network sustaining and driving leukemia development by activating several signaling cascades associated with drug-resistance and poor outcome. These aspects and their possible therapeutic implications are highlighted in this review.
Keywords: lipid phosphatase; PI3K/Akt/mTOR; genetic anomalies; targeted therapy; prognosis lipid phosphatase; PI3K/Akt/mTOR; genetic anomalies; targeted therapy; prognosis

Share and Cite

MDPI and ACS Style

Martelli, A.M.; Paganelli, F.; Fazio, A.; Bazzichetto, C.; Conciatori, F.; McCubrey, J.A. The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response. Cancers 2019, 11, 629. https://doi.org/10.3390/cancers11050629

AMA Style

Martelli AM, Paganelli F, Fazio A, Bazzichetto C, Conciatori F, McCubrey JA. The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response. Cancers. 2019; 11(5):629. https://doi.org/10.3390/cancers11050629

Chicago/Turabian Style

Martelli, Alberto M., Francesca Paganelli, Antonietta Fazio, Chiara Bazzichetto, Fabiana Conciatori, and James A. McCubrey. 2019. "The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response" Cancers 11, no. 5: 629. https://doi.org/10.3390/cancers11050629

APA Style

Martelli, A. M., Paganelli, F., Fazio, A., Bazzichetto, C., Conciatori, F., & McCubrey, J. A. (2019). The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response. Cancers, 11(5), 629. https://doi.org/10.3390/cancers11050629

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop