Next Article in Journal
Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells
Next Article in Special Issue
Recommendations Favoring Anal Cytology as a Method for Anal Cancer Screening: A Systematic Review
Previous Article in Journal
Immunological Effects of Epigenetic Modifiers
Previous Article in Special Issue
Evaluation of the Accuracy of Liquid-Based Oral Brush Cytology in Screening for Oral Squamous Cell Carcinoma
Open AccessArticle

A 4-Year Retrospective Analysis of Salivary Gland Cytopathology Using the Milan System for Reporting Salivary Gland Cytology and Ancillary Studies

1
Department of Cytology and Pathology, Toulouse Cancer University Institute, CHU Toulouse, CEDEX, 31059 Toulouse, France
2
Rangueil Faculty of Medicine, Paul Sabatier University, Toulouse-3, CEDEX, 31062 Toulouse, France
3
INSERM UMR 1037, Centre for Cancer Research of Toulouse, 31062 Toulouse, France
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(12), 1912; https://doi.org/10.3390/cancers11121912
Received: 18 October 2019 / Revised: 21 November 2019 / Accepted: 28 November 2019 / Published: 1 December 2019
(This article belongs to the Special Issue Cytologic Features of Tumor)
The cytopathology of salivary glands presents major challenges due to the heterogeneity of benign and malignant neoplasms, which is reflected in the large range of WHO 2017 Classifications. Fine needle aspiration (FNA) of salivary gland tumours is still the favoured initial approach as it results in good sensitivity and specificity. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was published in 2018 and comprises seven categories. We report results from a 4-year retrospective analysis of 328 salivary gland FNAs which were reviewed and classified according to the MSRSGC. We assess the risk of neoplasm, the risk of malignancy and the contribution of ancillary studies to the diagnosis. Benign neoplasms were the most frequent diagnosis (44.2%). Malignant and suspicious for malignancy were identified in 11.3% and 4.9% of diagnosed cases, respectively. Histopathological analysis after surgery was available for 216 (65.8%) of the cases. All malignant cases were confirmed post-surgery, and 68.8% of suspicious for malignancy were confirmed as malignant tumours. Immunocytochemistry was informative in 72.3% of cases. Immunocytochemistry and FISH provided the definitive diagnosis in 23.7% and 33% of cases, respectively. In conclusion, the MSRSGC is more effective when specific features of neoplasms can be identified. Ancillary studies help to further characterise salivary gland tumours and thereby increase the accuracy of MSRSGC.
Keywords: salivary gland cytopathology; fine needle aspiration; The Milan System for Reporting Salivary Gland Cytopathology; immunocytochemistry; FISH salivary gland cytopathology; fine needle aspiration; The Milan System for Reporting Salivary Gland Cytopathology; immunocytochemistry; FISH
MDPI and ACS Style

Dubucs, C.; Basset, C.; D'Aure, D.; Courtade-Saïdi, M.; Evrard, S.M. A 4-Year Retrospective Analysis of Salivary Gland Cytopathology Using the Milan System for Reporting Salivary Gland Cytology and Ancillary Studies. Cancers 2019, 11, 1912.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop