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Epigenetic Regulation of p21cip1/waf1 in Human Cancer
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The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

Department of Biology, and Center for Drug Discovery, American University of Beirut, Beirut 1103, Lebanon
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Cancers 2019, 11(10), 1475; https://doi.org/10.3390/cancers11101475
Received: 18 June 2019 / Revised: 26 July 2019 / Accepted: 30 July 2019 / Published: 30 September 2019
(This article belongs to the Special Issue p21 – An Underestimated Driver for Cancers)
p21cip1/waf1 mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Significant advances have been made in elucidating the potential role of p21 in promoting tumorigenesis. Here, we discuss the involvement of p21 in multiple signaling pathways, its dual role in cancer, and the importance of understanding its paradoxical functions for effectively designing therapeutic strategies that could selectively inhibit its oncogenic activities, override resistance to therapy and yet preserve its tumor suppressive functions. View Full-Text
Keywords: p21; signaling pathways; cell cycle; dual role; cancer therapy; chemoresistance p21; signaling pathways; cell cycle; dual role; cancer therapy; chemoresistance
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Al Bitar, S.; Gali-Muhtasib, H. The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics. Cancers 2019, 11, 1475.

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