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Open AccessReview

Recommendations and Choices for BRCA Mutation Carriers at Risk for Ovarian Cancer: A Complicated Decision

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Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
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Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
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The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(2), 57; https://doi.org/10.3390/cancers10020057
Received: 7 December 2017 / Revised: 14 February 2018 / Accepted: 16 February 2018 / Published: 21 February 2018
Current ovarian cancer screening guidelines in high-risk women vary according to different organizations. Risk reducing surgery remains the gold standard for definitive treatment in BRCA mutation carriers, but research advancements have created more short-term options for patients to consider. The decisions involved in how a woman manages her BRCA mutation status can cause a great deal of stress and worry due to the imperfect therapy options. The goal of this review was to critically analyze the screening recommendations and alternative options for high-risk ovarian cancer patients and evaluate how these discrepancies and choices affect a woman’s management decisions. View Full-Text
Keywords: BRCA; ovarian cancer; risk-reducing surgery; CA-125; screening guidelines BRCA; ovarian cancer; risk-reducing surgery; CA-125; screening guidelines
MDPI and ACS Style

Lewis, K.E.; Lu, K.H.; Klimczak, A.M.; Mok, S.C. Recommendations and Choices for BRCA Mutation Carriers at Risk for Ovarian Cancer: A Complicated Decision. Cancers 2018, 10, 57.

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