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Advanced EUS Guided Tissue Acquisition Methods for Pancreatic Cancer

Department of Gastroenterology and Hepatology Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA
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Author to whom correspondence should be addressed.
Cancers 2018, 10(2), 54; https://doi.org/10.3390/cancers10020054
Received: 8 December 2017 / Revised: 9 February 2018 / Accepted: 11 February 2018 / Published: 17 February 2018
(This article belongs to the Special Issue Latest Development in Pancreatic Cancer)
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PDF [249 KB, uploaded 21 February 2018]

Abstract

Pancreas cancer is a lethal cancer as the majority patients are diagnosed at an advanced incurable stage. Despite improvements in diagnostic modalities and management strategies, including surgery and chemotherapies, the outcome of pancreas cancer remains poor. Endoscopic ultrasound (EUS) is an important imaging tool for pancreas cancer. For decades, resected pancreas cancer and other cancer specimens have been used to identify tissue biomarkers or genomics for precision therapy; however, only 20% of patients undergo surgery, and thus, this framework is not useful for unresectable pancreas cancer. With advancements in needle technologies, tumor specimens can be obtained at the time of tissue diagnosis. Tumor tissue can be used for development of personalized cancer treatment, such as performing whole exome sequencing and global genomic profiling of pancreas cancer, development of tissue biomarkers, and targeted mutational assays for precise chemotherapy treatment. In this review, we discuss the recent advances in tissue acquisition of pancreas cancer. View Full-Text
Keywords: pancreas cancer; endoscopic ultrasound; precision therapy pancreas cancer; endoscopic ultrasound; precision therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kandel, P.; Wallace, M.B. Advanced EUS Guided Tissue Acquisition Methods for Pancreatic Cancer. Cancers 2018, 10, 54.

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