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Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review

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Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China
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Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Genetics Institute and McKnight Brain Institute, Shands Cancer Center, University of Florida, Gainesville, FL 32611-7200, USA
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State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
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College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
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Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
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Author to whom correspondence should be addressed.
Cancers 2018, 10(2), 47; https://doi.org/10.3390/cancers10020047
Received: 17 December 2017 / Revised: 24 January 2018 / Accepted: 25 January 2018 / Published: 9 February 2018
(This article belongs to the Special Issue Aptamers: Promising Tools for Cancer Diagnosis and Therapy)
Currently, functional single-stranded oligonucleotide probes, termed aptamers, generated by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment (SELEX), are utilized to selectively target molecules or cells with high affinity. Aptamers hold considerable promise as multifunctional molecules or conjugates for challenging nanotechnologies or bioapplications now and in the future. In this review, we first describe recent endeavors to select aptamers towards live cancer cells via cell-SELEX. We then introduce several characteristic applications of selected aptamers, especially in imaging, drug delivery and therapy. In part, these advances have been made possible via synthesis of aptamer-based nanomaterials, which, by their sizes, shapes, and physicochemical properties, allow such aptamer-nanomaterial complexes to function as signal reporters or drug carriers. We also describe how these aptamer-based molecular tools contribute to cancer biomarker discovery through high-affinity recognition of membrane protein receptors. View Full-Text
Keywords: cell-SELEX; aptamer; cancer; imaging; drug delivery; therapy; biomarker cell-SELEX; aptamer; cancer; imaging; drug delivery; therapy; biomarker
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MDPI and ACS Style

Pang, X.; Cui, C.; Wan, S.; Jiang, Y.; Zhang, L.; Xia, L.; Li, L.; Li, X.; Tan, W. Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review. Cancers 2018, 10, 47. https://doi.org/10.3390/cancers10020047

AMA Style

Pang X, Cui C, Wan S, Jiang Y, Zhang L, Xia L, Li L, Li X, Tan W. Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review. Cancers. 2018; 10(2):47. https://doi.org/10.3390/cancers10020047

Chicago/Turabian Style

Pang, Xuehui; Cui, Cheng; Wan, Shuo; Jiang, Ying; Zhang, Liangliang; Xia, Lian; Li, Long; Li, Xiaowei; Tan, Weihong. 2018. "Bioapplications of Cell-SELEX-Generated Aptamers in Cancer Diagnostics, Therapeutics, Theranostics and Biomarker Discovery: A Comprehensive Review" Cancers 10, no. 2: 47. https://doi.org/10.3390/cancers10020047

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