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EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs

1
School of Medicine, Deakin University, Geelong, VIC 3128, Australia
2
Centre for Comparative Genomics, Murdoch University, Perth, WA 6150, Australia
3
Perron Institute for Neurological and Translational Science, Perth, WA 6009, Australia
4
Department of Pathology and University of Melbourne, Melbourne, VIC 3010, Australia
5
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3000, Australia
6
Matrix Microenvironment and Metastasis Laboratory, Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia
7
Centre for Molecular and Medical Research, Deakin University, Geelong, VIC 3128, Australia
*
Author to whom correspondence should be addressed.
Cancers 2018, 10(1), 19; https://doi.org/10.3390/cancers10010019
Received: 18 December 2017 / Revised: 8 January 2018 / Accepted: 8 January 2018 / Published: 12 January 2018
(This article belongs to the Special Issue Aptamers: Promising Tools for Cancer Diagnosis and Therapy)
The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded. In this review, we look at the reasons why and consider alternative targeting options, such as aptamers, to turn this almost ubiquitously expressed epithelial cancer biomarker into a viable target for future personalized therapy. View Full-Text
Keywords: antibody; aptamer; cancer; EpCAM; immunotherapy; therapeutics antibody; aptamer; cancer; EpCAM; immunotherapy; therapeutics
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Macdonald, J.; Henri, J.; Roy, K.; Hays, E.; Bauer, M.; Veedu, R.N.; Pouliot, N.; Shigdar, S. EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. Cancers 2018, 10, 19.

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