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Novel Agents for Acute Myeloid Leukemia

Section of Hematology Department of Medical and Surgical Sciences, Azienda Ospedaliera Universitaria di Modena Università di Modena e Reggio Emilia, 41125 Modena, Italy
Division of Hematology and Bone Marrow Transplantation, Ospedali Riuniti Villa Sofia-Cervello, 90146 Palermo, Italy
Hematology and Transplant Center, Azienda Ospedaliera Marche Nord, 61121 Pesaro, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola (FC), Italy
Hematology, Department of Biomedicine and Prevention, “Tor Vergata” University of Rome, 00133 Roma, Italy
Author to whom correspondence should be addressed.
Cancers 2018, 10(11), 429;
Received: 1 October 2018 / Revised: 5 November 2018 / Accepted: 6 November 2018 / Published: 9 November 2018
Acute myeloid leukemia (AML) is a complex hematological disease characterized by genetic and clinical heterogeneity. Recent advances in the understanding of AML pathogenesis have paved the way for the development of new agents targeting specific molecules or mechanisms that contribute to finally move beyond the current standard of care, which is “3 + 7” regimen. In particular, new therapeutic options such as targeted therapies (midostaurin and enasidenib), monoclonal antibodies (gemtuzumab ozogamicin), and a novel liposomal formulation of cytarabine and daunorubicin (CPX-351) have been recently approved, and will be soon available for the treatment of adult patients with AML. In this review, we will present and describe these recently approved drugs as well as selected novel agents against AML that are currently under investigation, and show the most promising results as monotherapy or in combination with chemotherapy. The selection of these emerging treatments is based on the authors’ opinion. View Full-Text
Keywords: acute myeloid leukemia; “7 + 3” regimen; gemtuzumab ozogamicin; CPX-351; FLT3; midostaurin; enasidenib; palliative care acute myeloid leukemia; “7 + 3” regimen; gemtuzumab ozogamicin; CPX-351; FLT3; midostaurin; enasidenib; palliative care
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Luppi, M.; Fabbiano, F.; Visani, G.; Martinelli, G.; Venditti, A. Novel Agents for Acute Myeloid Leukemia. Cancers 2018, 10, 429.

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