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Cancers 2018, 10(10), 378; https://doi.org/10.3390/cancers10100378

Tumor Location Influences Oncologic Outcomes of Hepatocellular Carcinoma Patients Undergoing Radiofrequency Ablation

1
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China
2
Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China
3
Department of Radiology, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China
*
Authors to whom correspondence should be addressed.
Jinbin Chen and Kangqiang Peng contributed equally to this work.
Received: 10 September 2018 / Revised: 4 October 2018 / Accepted: 8 October 2018 / Published: 10 October 2018
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PDF [1678 KB, uploaded 10 October 2018]
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Abstract

Radiofrequency ablation (RFA) is recommended as a first-line therapy for small hepatocellular carcinoma (HCC). Tumor location is a potential factor influencing the procedure of RFA. To compare oncologic outcomes of RFA for different tumor locations, this retrospective study enrolled 194 patients with small HCC who had undertaken RFA. The HCC nodules were classified as peri-hepatic-vein (pHV) or non-pHV, peri-portal-vein (pPV) or non-pPV, and subcapsular or non-subcapsular HCC. The regional recurrence-free survival (rRFS), overall survival (OS), recurrence-free survival (recurrence in any location, RFS) and distant recurrence-free survival (dRFS) were compared. Operation failures were recorded in five pPV HCC patients, which was more frequent than in non-pPV HCC patients (p = 0.041). The 1-, 3-, and 5-year rRFS was 68.7%, 53.7%, and 53.7% for pHV patients and 85.1%, 76.1%, and 71.9% for non-pHV patients, respectively (p = 0.012). After propensity score matching, the 1-, 3-, and 5-year rRFS was still worse than that of non-pHV patients (p = 0.013). The OS, RFS, and dRFS were not significantly different between groups. Conclusions: A pHV location was a risk factor for the regional recurrence after RFA in small HCC patients. The tumor location may not influence OS, RFS, and dRFS. Additionally, a pPV location was a potential high-risk factor for incomplete ablation. View Full-Text
Keywords: hepatocellular carcinoma; radiofrequency ablation; recurrence; tumor location; prognosis hepatocellular carcinoma; radiofrequency ablation; recurrence; tumor location; prognosis
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Chen, J.; Peng, K.; Hu, D.; Shen, J.; Zhou, Z.; Xu, L.; Chen, J.; Pan, Y.; Wang, J.; Zhang, Y.; Chen, M. Tumor Location Influences Oncologic Outcomes of Hepatocellular Carcinoma Patients Undergoing Radiofrequency Ablation. Cancers 2018, 10, 378.

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