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JNK, p38, ERK, and SGK1 Inhibitors in Cancer

Department for Microbiology, Immunbiology und Genetics, Max F. Perutz Laboratories, University of Vienna, Vienna AT-1030, Austria
Proteomics Centre, Institute of Biochemistry, Vilnius University, 01513 Vilnius, Lithuania
MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, CH-3027 Bern, Switzerland
Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania
Department of Biology and Chemistry, Lithuanian University of Educational Sciences, 08106 Vilnius, Lithuania
Cardiovascular Research Centre, Viborg Hospital, Heibergs Alle 4, 8800 Viborg, Denmark
Author to whom correspondence should be addressed.
Cancers 2018, 10(1), 1;
Received: 25 October 2017 / Revised: 14 December 2017 / Accepted: 19 December 2017 / Published: 21 December 2017
(This article belongs to the Collection Kinases and Cancer)
PDF [1068 KB, uploaded 21 December 2017]


Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a range of biological processes implicated in the response to growth factors like latelet-derived growth factor (PDGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and stress, such as ultraviolet irradiation, heat shock, and osmotic shock. The MAP kinase family consists of four major subfamilies of related proteins (extracellular regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), p38, and extracellular regulated kinase 5 (ERK5)) and regulates numerous cellular activities, such as apoptosis, gene expression, mitosis, differentiation, and immune responses. The deregulation of these kinases is shown to be involved in human diseases, such as cancer, immune diseases, inflammation, and neurodegenerative disorders. The awareness of the therapeutic potential of the inhibition of MAP kinases led to a thorough search for small-molecule inhibitors. Here, we discuss some of the most well-known MAP kinase inhibitors and their use in cancer research. View Full-Text
Keywords: JNK; p38; ERK; SGK1; kinase inhibitors; cancer; MAP kinases JNK; p38; ERK; SGK1; kinase inhibitors; cancer; MAP kinases

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Cicenas, J.; Zalyte, E.; Rimkus, A.; Dapkus, D.; Noreika, R.; Urbonavicius, S. JNK, p38, ERK, and SGK1 Inhibitors in Cancer. Cancers 2018, 10, 1.

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