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Micromachines 2017, 8(11), 329;

Label-Free Monitoring of Diffusion in Microfluidics

Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby 2800, Denmark
Author to whom correspondence should be addressed.
Received: 12 October 2017 / Revised: 3 November 2017 / Accepted: 6 November 2017 / Published: 9 November 2017
(This article belongs to the Special Issue Optofluidics: From Fundamental Research to Applications)
Full-Text   |   PDF [1203 KB, uploaded 9 November 2017]   |  


Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa). View Full-Text
Keywords: optofluidics; microfluidics; diffusion; convection; mixing; refractive index; label-free optofluidics; microfluidics; diffusion; convection; mixing; refractive index; label-free

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Tølbøl Sørensen, K.; Kristensen, A. Label-Free Monitoring of Diffusion in Microfluidics. Micromachines 2017, 8, 329.

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