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Open AccessFeature PaperArticle

Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding

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IFN CNR, Institute for Photonics and Nanotechnologies, National Research Council, Piazza Leonardo da Vinci, 32, 20133 Milan, Italy
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ITIA CNR, Institute of Industrial Technology and Automation, National Research Council, Via P. Lembo 38F, 70124 Bari, Italy
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IFN CNR, Institute for Photonics and Nanotechnologies, National Research Council, Via Amendola 173, 70126 Bari, Italy
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ISASI CNR, Institute of Applied Sciences & Intelligent Systems “E. Caianiello”, Via Torre Bianca—Istituto Marino Pad. 4 Mortelle, 98164 Messina, Italy
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ISASI CNR, Institute of Applied Sciences & Intelligent Systems “E. Caianiello”, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
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ITIA CNR, Institute of Industrial Technology and Automation, National Research Council, Via A. Corti 12, 20133 Milan, Italy
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Author to whom correspondence should be addressed.
Micromachines 2017, 8(11), 328; https://doi.org/10.3390/mi8110328
Received: 10 October 2017 / Revised: 31 October 2017 / Accepted: 3 November 2017 / Published: 7 November 2017
(This article belongs to the Special Issue Ultrafast Laser Fabrication for Lab-on-a-Chip)
We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production. View Full-Text
Keywords: lab-on-a-chip; micro-injection-molding; femtosecond laser micromachining; fluorescent cytometry; cell phone lab-on-a-chip; micro-injection-molding; femtosecond laser micromachining; fluorescent cytometry; cell phone
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MDPI and ACS Style

Martínez Vázquez, R.; Trotta, G.; Volpe, A.; Bernava, G.; Basile, V.; Paturzo, M.; Ferraro, P.; Ancona, A.; Fassi, I.; Osellame, R. Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding. Micromachines 2017, 8, 328. https://doi.org/10.3390/mi8110328

AMA Style

Martínez Vázquez R, Trotta G, Volpe A, Bernava G, Basile V, Paturzo M, Ferraro P, Ancona A, Fassi I, Osellame R. Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding. Micromachines. 2017; 8(11):328. https://doi.org/10.3390/mi8110328

Chicago/Turabian Style

Martínez Vázquez, Rebeca; Trotta, Gianluca; Volpe, Annalisa; Bernava, Giuseppe; Basile, Vito; Paturzo, Melania; Ferraro, Pietro; Ancona, Antonio; Fassi, Irene; Osellame, Roberto. 2017. "Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding" Micromachines 8, no. 11: 328. https://doi.org/10.3390/mi8110328

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