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Open AccessReview

Recent Advances in Monitoring Cell Behavior Using Cell-Based Impedance Spectroscopy

Department of Physical and Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada
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Author to whom correspondence should be addressed.
These authors contributed equally.
Micromachines 2020, 11(6), 590; https://doi.org/10.3390/mi11060590
Received: 4 May 2020 / Revised: 5 June 2020 / Accepted: 9 June 2020 / Published: 13 June 2020
(This article belongs to the Special Issue Micro and Nano Devices for Cell Analysis)
Cell-based impedance spectroscopy (CBI) is a powerful tool that uses the principles of electrochemical impedance spectroscopy (EIS) by measuring changes in electrical impedance relative to a voltage applied to a cell layer. CBI provides a promising platform for the detection of several properties of cells including the adhesion, motility, proliferation, viability and metabolism of a cell culture. This review gives a brief overview of the theory, instrumentation, and detection principles of CBI. The recent applications of the technique are given in detail for research into cancer, neurodegenerative diseases, toxicology as well as its application to 2D and 3D in vitro cell cultures. CBI has been established as a biophysical marker to provide quantitative cellular information, which can readily be adapted for single-cell analysis to complement the existing biomarkers for clinical research on disease progression. View Full-Text
Keywords: cell-based impedance; cell culture; electrochemical impedance spectroscopy; high-throughput screening cell-based impedance; cell culture; electrochemical impedance spectroscopy; high-throughput screening
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Hassan, Q.; Ahmadi, S.; Kerman, K. Recent Advances in Monitoring Cell Behavior Using Cell-Based Impedance Spectroscopy. Micromachines 2020, 11, 590.

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