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Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor

Department of Mechanical Science and Engineering, Faculty of Science and Technology, Hirosaki University, 3 Bunkyo-cho, Hirosaki 036-8561, Japan
Laboratory of Pathology and Clinical Research, Aichi Cancer Center Aichi Hospital, Okazaki 444-0011, Japan
Graduate School of Informatics, Nagoya University, Nagoya 464-8601, Japan
Research Center for Medical Bigdata, National Institute of Informatics, Tokyo 101-8430, Japan
Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya 468-0073, Japan
Department of Media Engineering, School of Engineering, Chukyo University, Nagoya 466-8666, Japan
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan
Department of Electrical Engineering and Electronics, College of Science and Engineering, Aoyama Gakuin University, Kanagawa 252-5258, Japan
Author to whom correspondence should be addressed.
Micromachines 2019, 10(2), 81;
Received: 19 December 2018 / Revised: 11 January 2019 / Accepted: 19 January 2019 / Published: 24 January 2019
(This article belongs to the Special Issue Infrared Nanophotonics: Materials, Devices, and Applications)
PDF [2484 KB, uploaded 31 January 2019]
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Laparoscopic surgery is now a standard treatment for gastric cancer. Currently, the location of the gastric cancer is identified during laparoscopic surgery via the preoperative endoscopic injection of charcoal ink around the primary tumor; however, the wide spread of injected charcoal ink can make it difficult to accurately visualize the specific site of the tumor. To precisely identify the locations of gastric tumors, we developed a fluorescent detection system comprising clips with glass phosphor (Yb3+, Nd3+ doped to Bi2O3-B2O3-based glasses, size: 2 mm × 1 mm × 3 mm) fixed in the stomach and a laparoscopic fluorescent detection system for clip-derived near-infrared (NIR) light (976 nm). We conducted two ex vivo experiments to evaluate the performance of this fluorescent detection system in an extirpated pig stomach and a freshly resected human stomach and were able to successfully detect NIR fluorescence emitted from the clip in the stomach through the stomach wall by the irradiation of excitation light (λ: 808 nm). These results suggest that the proposed combined NIR light-emitting clip and laparoscopic fluorescent detection system could be very useful in clinical practice for accurately identifying the location of a primary gastric tumor during laparoscopic surgery. View Full-Text
Keywords: gastric cancer; laparoscopic surgery; fluorescent clip; near-infrared fluorescence imaging gastric cancer; laparoscopic surgery; fluorescent clip; near-infrared fluorescence imaging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Inada, S.A.; Nakanishi, H.; Oda, M.; Mori, K.; Ito, A.; Hasegawa, J.; Misawa, K.; Fuchi, S. Development of a New Laparoscopic Detection System for Gastric Cancer Using Near-Infrared Light-Emitting Clips with Glass Phosphor. Micromachines 2019, 10, 81.

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