Next Article in Journal
Dextran as a Resorbable Coating Material for Flexible Neural Probes
Previous Article in Journal
A Compact Broadband Antenna with Dual-Resonance for Implantable Devices
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Micromachines 2019, 10(1), 60; https://doi.org/10.3390/mi10010060

Empirical Modeling of Zn/ZnO Nanoparticles Decorated/Conjugated with Fotolon (Chlorine e6) Based Photodynamic Therapy towards Liver Cancer Treatment

1
Department of Physics, Government College University, Faisalabad 38000, Pakistan
2
Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
3
Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11543, Saudi Arabia
4
Department of Physics, University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan
5
School of Physics, Dalian University of Technology, Dalian 116024, China
6
School of Microelectronics, Dalian University of Technology, Dalian 116024, China
7
Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11543, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Received: 28 November 2018 / Revised: 8 January 2019 / Accepted: 8 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Micro/Nano-system for Drug Delivery)
Full-Text   |   PDF [4245 KB, uploaded 17 January 2019]   |  

Abstract

The current study is based on Zn/ZnO nanoparticles photodynamic therapy (PDT) mediated effects on healthy liver cells and cancerous cells. The synthesis of Zn/ZnO nanoparticles was accomplished using chemical and hydrothermal methods. The characterization of the synthesized nanoparticles was carried out using manifold techniques (e.g., transmission electron microscopy (TEM), X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDS)). In order to study the biotoxicity of the grown nanoparticles, they were applied individually and in conjunction with the third generation photosensitiser Fotolon (Chlorine e6) in the in vivo model of the normal liver of the Wister rat, and in the in vitro cancerous liver (HepG2) model both in the dark and under a variety of laser exposures (630 nm, Ultraviolet (UV) light). The localization of ZnO nanoparticles was observed by applying fluorescence spectroscopy on a 1 cm2 selected area of normal liver, whereas the in vitro cytotoxicity and reactive oxygen species (ROS) detection were carried out by calculating the loss in the cell viability of the hepatocellular model by applying a neutral red assay (NRA). Furthermore, a statistical analysis is carried out and it is ensured that the p value is less than 0.05. Thus, the current study has highlighted the potential for applying Zn/ZnO nanoparticles in photodynamic therapy that would lead to wider medical applications to improve the efficiency of cancer treatment and its biological aspect study. View Full-Text
Keywords: ZnO nanoparticles; photodynamic therapy; photosensitizer; hepatocellular model; bio toxicity ZnO nanoparticles; photodynamic therapy; photosensitizer; hepatocellular model; bio toxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Iqbal, S.; Fakhar-e-Alam, M.; Atif, M.; Ahmed, N.; -ul-Ahmad, A.; Amin, N.; Alghamdi, R.; Hanif, A.; Farooq, W.A. Empirical Modeling of Zn/ZnO Nanoparticles Decorated/Conjugated with Fotolon (Chlorine e6) Based Photodynamic Therapy towards Liver Cancer Treatment. Micromachines 2019, 10, 60.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Micromachines EISSN 2072-666X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top