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Toxins 2018, 10(11), 465; https://doi.org/10.3390/toxins10110465

Dose and Exposure Time-Dependent Renal and Hepatic Effects of Intraperitoneally Administered Fumonisin B1 in Rats

1
MTA-KE-SZIE Mycotoxins in the Food Chain Research Group, Kaposvár University, Guba S. u. 40., 7400 Kaposvár, Hungary
2
Faculty of Agricultural and Environmental Sciences, Kaposvár University, Guba S. 40., 7400 Kaposvár, Hungary
3
Somogy County Kaposi Mór Teaching Hospital, Dr. József Baka Diagnostical, Oncoradiological, Research and Educational Center, Guba S. u. 40., 7400 Kaposvár, Hungary
4
Faculty of Agricultural and Environmental Sciences, Department of Nutrition, Szent István University, Páter K. u. 1., 2013 Gödöllő, Hungary
5
Autopsy Ltd., Telepes u. 42., 1147 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Received: 15 October 2018 / Revised: 2 November 2018 / Accepted: 7 November 2018 / Published: 9 November 2018
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

Male Wistar rats were treated intraperitoneally (i.p.) with fumonisin B1 (FB1; 0, 20, 50 and 100 mg/kg dietary dose equivalent) for 5 and 10 days (n = 24–24 in each setting) to gain dose- and time-dependent effects on antioxidant status and oxidative stress response, clinical chemical endpoints and liver, kidney and lung histopathology and lymphocyte damage (genotoxicity). FB1 decreased feed intake, body weight gain and absolute liver weight, irrespective of the toxin dose. Relative kidney weight increased in the 10-day setting. Linear dose response was found for plasma aspartate aminotransferase, alanine aminotransferase, total cholesterol, urea and creatinine, and exposure time-dependence for plasma creatinine level. The latter was coupled with renal histopathological findings, tubular degeneration and necrosis and the detachment of tubular epithelial cells. The pronounced antioxidant response (reduced glutathione accretion, increasing glutathione peroxidase activity) referred to renal cortical response (5–10 days exposure at 50–100 ppm FB1). Hepatic alterations were moderate, referring to initial phase lipid peroxidation (exposure time dependent difference of conjugated diene and triene concentrations), and slight functional disturbance (↑ total cholesterol). Lymphocyte DNA damage was moderate, supporting a mild genotoxic effect of FB1. View Full-Text
Keywords: fumonisin B1; rat; dose-dependence; hepatotoxicity; nephrotoxicity; genotoxicity fumonisin B1; rat; dose-dependence; hepatotoxicity; nephrotoxicity; genotoxicity
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Szabó, A.; Szabó-Fodor, J.; Kachlek, M.; Mézes, M.; Balogh, K.; Glávits, R.; Ali, O.; Zeebone, Y.Y.; Kovács, M. Dose and Exposure Time-Dependent Renal and Hepatic Effects of Intraperitoneally Administered Fumonisin B1 in Rats. Toxins 2018, 10, 465.

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