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The Roles of Vitamin C in Skin Health

Department of Pathology, University of Otago, Christchurch, P.O. Box 4345, Christchurch 8140, New Zealand
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Nutrients 2017, 9(8), 866; https://doi.org/10.3390/nu9080866
Received: 10 July 2017 / Revised: 7 August 2017 / Accepted: 9 August 2017 / Published: 12 August 2017
(This article belongs to the Special Issue Vitamin C in Health and Disease)
The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage. This knowledge is often used as a rationale for the addition of vitamin C to topical applications, but the efficacy of such treatment, as opposed to optimising dietary vitamin C intake, is poorly understood. This review discusses the potential roles for vitamin C in skin health and summarises the in vitro and in vivo research to date. We compare the efficacy of nutritional intake of vitamin C versus topical application, identify the areas where lack of evidence limits our understanding of the potential benefits of vitamin C on skin health, and suggest which skin properties are most likely to benefit from improved nutritional vitamin C intake. View Full-Text
Keywords: ascorbate; dermis; epidermis; skin barrier function; vitamin C status; skin aging; wound healing; collagen; UV protection ascorbate; dermis; epidermis; skin barrier function; vitamin C status; skin aging; wound healing; collagen; UV protection
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Pullar, J.M.; Carr, A.C.; Vissers, M.C.M. The Roles of Vitamin C in Skin Health. Nutrients 2017, 9, 866.

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