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Article

Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study

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Biostatistics and Computational Biology Unit, University of Otago, Christchurch 8140, New Zealand
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Department of Pathology, University of Otago, Christchurch 8140, New Zealand
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Department of Medicine, University of Otago, Christchurch 8140, New Zealand
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Department of Psychological Medicine, University of Otago, Christchurch 8140, New Zealand
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Department of Human Nutrition, University of Otago, Dunedin 9054, New Zealand
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Lipid & Diabetes Research Group, Canterbury District Health Board, Christchurch 8140, New Zealand
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(8), 831; https://doi.org/10.3390/nu9080831
Received: 14 July 2017 / Revised: 27 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Vitamin C in Health and Disease)
A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2 µmol/L (95% CI 42.4, 46.0); 62% of the cohort had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L), 13% of the cohort had hypovitaminosis C (i.e., <23 µmol/L), and 2.4% had plasma vitamin C concentrations indicating deficiency (i.e., <11 µmol/L). Men had a lower mean plasma vitamin C concentration than women, and a higher percentage of vitamin C inadequacy and deficiency. A higher prevalence of hypovitaminosis C and deficiency was observed in those of lower socio-economic status and in current smokers. Adults with higher vitamin C levels exhibited lower weight, BMI and waist circumference, and better measures of metabolic health, including HbA1c, insulin and triglycerides, all risk factors for type 2 diabetes. Lower levels of mild cognitive impairment were observed in those with the highest plasma vitamin C concentrations. Plasma vitamin C showed a stronger correlation with markers of metabolic health and cognitive impairment than dietary vitamin C. View Full-Text
Keywords: ascorbate; cognition; HbA1c; insulin; glucose; hypovitaminosis C ascorbate; cognition; HbA1c; insulin; glucose; hypovitaminosis C
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MDPI and ACS Style

Pearson, J.F.; Pullar, J.M.; Wilson, R.; Spittlehouse, J.K.; Vissers, M.C.M.; Skidmore, P.M.L.; Willis, J.; Cameron, V.A.; Carr, A.C. Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study. Nutrients 2017, 9, 831. https://doi.org/10.3390/nu9080831

AMA Style

Pearson JF, Pullar JM, Wilson R, Spittlehouse JK, Vissers MCM, Skidmore PML, Willis J, Cameron VA, Carr AC. Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study. Nutrients. 2017; 9(8):831. https://doi.org/10.3390/nu9080831

Chicago/Turabian Style

Pearson, John F., Juliet M. Pullar, Renee Wilson, Janet K. Spittlehouse, Margreet C.M. Vissers, Paula M.L. Skidmore, Jinny Willis, Vicky A. Cameron, and Anitra C. Carr 2017. "Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study" Nutrients 9, no. 8: 831. https://doi.org/10.3390/nu9080831

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