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Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells

by Yan Ma 1,2, Xiaoyi Wang 1,2, Hongying Yang 3, Xu Zhang 1,2 and Nianhong Yang 1,2,*
1
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3
Hubei Provincial Center for Disease Control and Prevention, Wuhan 430030, China
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(6), 626; https://doi.org/10.3390/nu9060626
Received: 4 May 2017 / Revised: 3 June 2017 / Accepted: 15 June 2017 / Published: 17 June 2017
Central nervous system (CNS) fatty acid sensing plays an important role in the regulation of food intake, and palmitic acid (PA) is the most important long chain fatty acid (LCFA) in the mammalian diet. To explore the effect of PA on central neuropeptide expression and the role of the cluster of the differentiation of 36 (CD36) in the process, N1E-115 cells were cultured with PA in the presence or absence of sulfosuccinimidyl-oleate (SSO), a CD36 inhibitor. Results showed that 10 μmol/L PA significantly reduced NPY and AgRP mRNA expression after 20 min of exposure, while the expression of CD36 was upregulated. The presence of SSO significantly attenuated the decrease of NPY and AgRP expression that was induced by PA alone, although no notable effect on PA- induced CD36 gene expression was observed. In conclusion, our study suggests the involvement of CD36 in the PA-induced decrease of NPY and AgRP in N1E-115 cells. View Full-Text
Keywords: palmitic acid; CD36; NPY; AgRP palmitic acid; CD36; NPY; AgRP
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Ma, Y.; Wang, X.; Yang, H.; Zhang, X.; Yang, N. Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells. Nutrients 2017, 9, 626.

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