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Review

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants

by
Ceren Daskaya-Dikmen
1,
Aysun Yucetepe
1,
Funda Karbancioglu-Guler
1,
Hayrettin Daskaya
2 and
Beraat Ozcelik
1,3,*
1
Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
2
Department of Anesthesia and Reanimation, Bezmialem Vakif University Medical Faculty, Istanbul 34093, Turkey
3
BIOACTIVE Research & Innovation Food Manufacturing Industry Trade LTD Co., Maslak, Istanbul 34469, Turkey
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(4), 316; https://doi.org/10.3390/nu9040316
Submission received: 30 December 2016 / Revised: 7 March 2017 / Accepted: 13 March 2017 / Published: 23 March 2017
(This article belongs to the Special Issue Selected papers from the 1st International Food Bioactives and Health Conference 2016)
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Abstract

Hypertension is an important factor in cardiovascular diseases. Angiotensin-I-converting enzyme (ACE) inhibitors like synthetic drugs are widely used to control hypertension. ACE-inhibitory peptides from food origins could be a good alternative to synthetic drugs. A number of plant-based peptides have been investigated for their potential ACE inhibitor activities by using in vitro and in vivo assays. These plant-based peptides can be obtained by solvent extraction, enzymatic hydrolysis with or without novel food processing methods, and fermentation. ACE-inhibitory activities of peptides can be affected by their structural characteristics such as chain length, composition and sequence. ACE-inhibitory peptides should have gastrointestinal stability and reach the cardiovascular system to show their bioactivity. This paper reviews the current literature on plant-derived ACE-inhibitory peptides including their sources, production and structure, as well as their activity by in vitro and in vivo studies and their bioavailability.
Keywords: angiotensin-I-converting enzyme inhibitory activity; bioactive peptides; plant proteins; enzymatic hydrolysis; bioavailability; obesity; diabetes angiotensin-I-converting enzyme inhibitory activity; bioactive peptides; plant proteins; enzymatic hydrolysis; bioavailability; obesity; diabetes

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MDPI and ACS Style

Daskaya-Dikmen, C.; Yucetepe, A.; Karbancioglu-Guler, F.; Daskaya, H.; Ozcelik, B. Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients 2017, 9, 316. https://doi.org/10.3390/nu9040316

AMA Style

Daskaya-Dikmen C, Yucetepe A, Karbancioglu-Guler F, Daskaya H, Ozcelik B. Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients. 2017; 9(4):316. https://doi.org/10.3390/nu9040316

Chicago/Turabian Style

Daskaya-Dikmen, Ceren, Aysun Yucetepe, Funda Karbancioglu-Guler, Hayrettin Daskaya, and Beraat Ozcelik. 2017. "Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants" Nutrients 9, no. 4: 316. https://doi.org/10.3390/nu9040316

APA Style

Daskaya-Dikmen, C., Yucetepe, A., Karbancioglu-Guler, F., Daskaya, H., & Ozcelik, B. (2017). Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants. Nutrients, 9(4), 316. https://doi.org/10.3390/nu9040316

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