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Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides

Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex‐Hacienda de la Concepción, Tilcuautla, Pachuca de Soto 42080, Hidalgo, México
Escuela Superior de Medicina, Instituto Politécnico Nacional, Unidad Casco de Santo Tomas, Plan de San Luis y Díaz Mirón s/n, México D.F. 11340, México
Secretaría de Investigación y Estudios de Posgrado, Universidad Autónoma de Nayarit, Ciudad de la Cultura Amado Nervo. Boulevard Tepic‐Xalisco s/n, Tepic 28000, Nayarit, México
Escuela Superior de Cómputo, Instituto Politécnico Nacional, Unidad A. López Mateos, Av. Juan de Dios Bátiz. Col., Lindavista, México D.F. 07738, Mexico
Laboratorio de Bioquímica Muscular, Instituto Nacional de Rehabilitación, Av. México‐Xochimilco. Col., Arenal de Guadalupe, México D.F. 14389, México
Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Unidad A. López‐Mateos, Av. Wilfrido Massieu s/n, Lindavista, México D.F. 07738, México
Author to whom correspondence should be addressed.
Nutrients 2017, 9(2), 102;
Received: 5 November 2016 / Accepted: 19 January 2017 / Published: 2 February 2017
Cancer is one of the leading causes of deaths worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens or teratogens. Genotoxins are involved in the pathogenesis of several chronic degenerative diseases including hepatic, neurodegenerative and cardiovascular disorders, diabetes, arthritis, cancer, chronic inflammation and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown potential antigenotoxicity in a variety of fruits. In this review (Part 1), we present an overview of research conducted on some fruits (grapefruit, cranberries, pomegranate, guava, pineapple, and mango) which are frequentl consumed by humans, as well as the analysis of some phytochemicals extracted from fruits and yeasts which have demonstrated antigenotoxic capacity in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus and comet assay. View Full-Text
Keywords: antigenotoxic; fruits; polysaccharides; chromosomal aberrations; cancer; micronucleus;  comet assay antigenotoxic; fruits; polysaccharides; chromosomal aberrations; cancer; micronucleus;  comet assay
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Izquierdo‐Vega, J.A.; Morales‐González, J.A.; SánchezGutiérrez, M.; Betanzos‐Cabrera, G.; Sosa‐Delgado, S.M.; Sumaya‐Martínez, M.T.; Morales‐González, Á.; Paniagua‐Pérez, R.; Madrigal‐Bujaidar, E.; Madrigal‐Santillán, E. Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides. Nutrients 2017, 9, 102.

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