Next Article in Journal
Study on the Prevalence of Severe Anemia among Non-Pregnant Women of Reproductive Age in Rural China: A Large Population-Based Cross-Sectional Study
Next Article in Special Issue
Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice
Previous Article in Journal
Nut Consumption and Cardiovascular Risk Factors: A Cross-Sectional Study in a Mediterranean Population
Previous Article in Special Issue
Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
Open AccessArticle

Dietary Sialyllactose Influences Sialic Acid Concentrations in the Prefrontal Cortex and Magnetic Resonance Imaging Measures in Corpus Callosum of Young Pigs

1
Piglet Nutrition & Cognition Lab, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
2
Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
3
Mead Johnson Pediatric Nutrition Institute, Mead Johnson Nutrition, 2400 W Lloyd Expressway, Evansville, IN 47712, USA
4
Division of Nutrition Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
5
Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(12), 1297; https://doi.org/10.3390/nu9121297
Received: 1 November 2017 / Revised: 22 November 2017 / Accepted: 23 November 2017 / Published: 28 November 2017
(This article belongs to the Special Issue Nutrition and the Function of the Central Nervous System)
Sialic acid (SA) is a key component of gangliosides and neural cell adhesion molecules important during neurodevelopment. Human milk contains SA in the form of sialyllactose (SL) an abundant oligosaccharide. To better understand the potential role of dietary SL on neurodevelopment, the effects of varying doses of dietary SL on brain SA content and neuroimaging markers of development were assessed in a newborn piglet model. Thirty-eight male pigs were provided one of four experimental diets from 2 to 32 days of age. Diets were formulated to contain: 0 mg SL/L (CON), 130 mg SL/L (LOW), 380 mg SL/L (MOD) or 760 mg SL/L (HIGH). At 32 or 33 days of age, all pigs were subjected to magnetic resonance imaging (MRI) to assess brain development. After MRI, pig serum and brains were collected and total, free and bound SA was analyzed. Results from this study indicate dietary SL influenced (p = 0.05) bound SA in the prefrontal cortex and the ratio of free SA to bound SA in the hippocampus (p = 0.04). Diffusion tensor imaging indicated treatment effects in mean (p < 0.01), axial (p < 0.01) and radial (p = 0.01) diffusivity in the corpus callosum. Tract-based spatial statistics (TBSS) indicated differences (p < 0.05) in white matter tracts and voxel-based morphometry (VBM) indicated differences (p < 0.05) in grey matter between LOW and MOD pigs. CONT and HIGH pigs were not included in the TBSS and VBM assessments. These findings suggest the corpus callosum, prefrontal cortex and hippocampus may be differentially sensitive to dietary SL supplementation. View Full-Text
Keywords: neurodevelopment; milk oligosaccharide; sialyllactose; pig; corpus callosum; sialic acid; pediatric nutrition neurodevelopment; milk oligosaccharide; sialyllactose; pig; corpus callosum; sialic acid; pediatric nutrition
Show Figures

Figure 1

MDPI and ACS Style

Mudd, A.T.; Fleming, S.A.; Labhart, B.; Chichlowski, M.; Berg, B.M.; Donovan, S.M.; Dilger, R.N. Dietary Sialyllactose Influences Sialic Acid Concentrations in the Prefrontal Cortex and Magnetic Resonance Imaging Measures in Corpus Callosum of Young Pigs. Nutrients 2017, 9, 1297.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop