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Nutrients 2018, 10(1), 1;

Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice

Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, TraianVuia 6, 020956 Bucharest, Romania
In Memoriam: The authors would like to respectfully dedicate this article to Prof. Aurelia Nicoleta Cristea who passed away on 24 November 2017.
Author to whom correspondence should be addressed.
Received: 27 September 2017 / Revised: 6 December 2017 / Accepted: 14 December 2017 / Published: 21 December 2017
(This article belongs to the Special Issue Nutrition and the Function of the Central Nervous System)
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Monosodium glutamate (MSG) is a widely used food additive. Although it is generally considered safe, some questions regarding the impact of its use on general health have arisen. Several reports correlate MSG consumption with a series of unwanted reactions, including headaches and mechanical sensitivity in pericranial muscles. Endogenous glutamate plays a significant role in nociceptive processing, this neurotransmitter being associated with hyperalgesia and central sensitization. One of the mechanisms underlying these phenomena is the stimulation of Ca2+/calmodulin sensitive nitric oxide synthase, and a subsequent increase in nitric oxide production. This molecule is a key player in nociceptive processing, with implications in acute and chronic pain states. Our purpose was to investigate the effect of this food additive on the nociceptive threshold when given orally to mice. Hot-plate and formalin tests were used to assess nociceptive behaviour. We also tried to determine if a correlation between chronic administration of MSG and variations in central nitric oxide (NO) concentration could be established. We found that a dose of 300 mg/kg MSG given for 21 days reduces the pain threshold and is associated with a significant increase in brain NO level. The implications of these findings on food additive-drug interaction, and on pain perception in healthy humans, as well as in those suffering from affections involving chronic pain, are still to be investigated. View Full-Text
Keywords: monosodium glutamate; hyperalgesia; hot-plate test; formalin test; nitric oxide synthase monosodium glutamate; hyperalgesia; hot-plate test; formalin test; nitric oxide synthase

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zanfirescu, A.; Cristea, A.N.; Nitulescu, G.M.; Velescu, B.S.; Gradinaru, D. Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice. Nutrients 2018, 10, 1.

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